Is gamma-Decalactone safe in cosmetics?
gamma-Decalactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
gamma-Decalactone
Also known as: 5-Hexyldihydro-2(3H)-furanone, (+/-)-4-n-Hexylbutyrolactone, (+/-)-γ-Decalactone, (+/-)-γ-Decanolactone, (RS)-γ-Decalactone (+14 more)
INCI: GAMMA-DECALACTONE
gamma-Decalactone (CAS 706-14-9) is a cosmetic cosmetic ingredient functioning as Fragrance / masking agent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 706-14-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / masking agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
5-hexyloxolan-2-one
InChIKey
IFYYFLINQYPWGJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific 21 CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for gamma-Decalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for gamma-Decalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 400 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS DB |
| NOAEL | 500 mg/kg bw/day | oral | mouse | Neurotoxicity | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for gamma-Decalactone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "706-14-9", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
231
Source: WHO/JECFA
JECFA Evaluation
4-HYDROXYDECANOIC ACID LACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
JECFA Evaluation
gamma-DECALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for gamma-Decalactone.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to gamma-Decalactone by CAS number or substance name.
Studies
2
Lowest NOAEL
400 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
COSMOS DB
Known Synonyms
5-Hexyldihydro-2(3H)-furanone
(+/-)-4-n-Hexylbutyrolactone
(+/-)-γ-Decalactone
(+/-)-γ-Decanolactone
(RS)-γ-Decalactone
NSC 24248
NSC 26510
5-17-09-00093
BRN 0117547
gamma-n-Decalactone
Decanoic acid, 4-hydroxy-, gamma-lactone
Decanoic acid, gamma-lactone
Decanolide-1,4
EINECS 211-892-8
FEMA No. 2360
gamma-Hexyl-gamma-butyrolactone
gamma-n-Hexyl-gamma-butyrolactone
4-Hexyl-gamma-butyrolactone
4-Hexyl-4-hydroxybutanoic acid lactone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL365740
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
GAMMA-DECALACTONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is gamma-Decalactone allowed in the EU?
gamma-Decalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Decalactone do in cosmetics?
gamma-Decalactone functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 706-14-9.
What is the NOAEL for gamma-Decalactone?
The NOAEL (No Observed Adverse Effect Level) for gamma-Decalactone is 400 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS DB.
Is gamma-Decalactone used outside cosmetics?
gamma-Decalactone also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check gamma-Decalactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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