What is the NOAEL for Gamma-Decanolactone?
Gamma-Decanolactone has 12 NOAEL studies in the database. The lowest reported value is 7HLS05KP9O UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gamma-Decanolactone
Also known as: 5-Hexyldihydro-2(3H)-furanone, (+/-)-4-n-Hexylbutyrolactone, (+/-)-γ-Decalactone, (+/-)-γ-Decanolactone, (RS)-γ-Decalactone (+15 more)
CAS 706-14-9
Gamma-Decanolactone (CAS 706-14-9) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
12
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Gamma-Decanolactone
CAS Number
706-14-9
DTXSID
DTXSID4022109
Molecular Formula
C10H18O2
InChI Key
IFYYFLINQYPWGJ-UHFFFAOYSA-N
Monoisotopic Mass
170.13068
Synonyms
5-Hexyldihydro-2(3H)-furanone(+/-)-4-n-Hexylbutyrolactone(+/-)-γ-Decalactone(+/-)-γ-Decanolactone(RS)-γ-DecalactoneNSC 24248NSC 265105-17-09-00093BRN 0117547gamma-Decalactonegamma-n-DecalactoneDecanoic acid, 4-hydroxy-, gamma-lactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7HLS05KP9O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7HLS05KP9O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7HLS05KP9O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7HLS05KP9O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| 400 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Decan-4-olide | 211-892-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL365740
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Gamma-Decanolactone?
Gamma-Decanolactone appears on 7 regulatory/inventory lists including Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 4 more. Source: EPA CPDat.
Is Gamma-Decanolactone used in cosmetics?
Yes, Gamma-Decanolactone is also indexed as a cosmetic ingredient under the name gamma-Decalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gamma-Decanolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Gamma-Decanolactone used outside industrial chemicals?
Gamma-Decanolactone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.