Name: gamma-Decalactone NOAEL Studies
Creator: Roots by Benda

COSMOS DB 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS DB	NOAEL	400	mg/kg bw/day	mouse	oral	1 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	500	mg/kg bw/day	mouse	oral	1 day	Neurotoxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study

EFSA 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA	NOAEL	=112	mg/kg bw/day	Rat	oral: gavage	730 days	chronic/long term toxicity	EFSA FEEDAP - 2012 - OutputID 616 - mortality - systemic - Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2928
EFSA	NOAEL	=112	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2928.; TITLE=Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2928; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15614765:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7cca86df752cbf79c336afa9f7e9dc83

NTP ICE endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=9914; RecordID=ARPathway2016_1506; DatasetName=ARPathway2016; DTXSID=DTXSID4022109; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022109

NTP ICE skin sensitization 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin sensitization	Incidence of positive responses	0	%	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9751; Record_ID=skin_sensitization_invivo_2161; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4022109; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM\|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80100-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022109
NTP ICE skin sensitization	Induction dose per skin area	6750	ug/cm2	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9750; Record_ID=skin_sensitization_invivo_2161; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4022109; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM\|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80100-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022109
NTP ICE skin sensitization	Relative reliability score	3	unitless	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9753; Record_ID=skin_sensitization_invivo_2161; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4022109; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM\|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80100-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022109

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	7HLS05KP9O	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7HLS05KP9O"}
openFDA substances	FDA UNII substance identifier	7HLS05KP9O	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7HLS05KP9O"}
openFDA substances	FDA UNII substance identifier	7HLS05KP9O	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7HLS05KP9O"}
openFDA substances	FDA UNII substance identifier	7HLS05KP9O	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7HLS05KP9O"}