Is Ethylhexylglycerin safe in cosmetics?
Ethylhexylglycerin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Ethylhexylglycerin
INCI: ETHYLHEXYLGLYCERIN
Ethylhexylglycerin (CAS 70445-33-9) is a cosmetic cosmetic ingredient functioning as preservative-booster, skin-conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 70445-33-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethylhexylglycerin is classified GHS Danger (H318, H332, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
preservative-booster, skin-conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap. Used at 0.3–0.8% as preservative booster in combination with phenoxyethanol. Surfactant-like structure enhances antimicrobial efficacy of phenoxyethanol by disrupting microbial cell membranes, permitting lower total phenoxyethanol doses.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylhexylglycerin.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Ethylhexylglycerin based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: ESSCA; IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ethylhexylglycerin, relevant to systemic exposure and MoS calculations.
Absorption %
8-15%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
204.3 Da
Log P
2.8
Systemic Absorption
minimal
Topical Bioavailability
5-12%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS Opinion
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Eye Dam. 1; Aquatic Chronic 3
Hazard Statements
- H318 Causes serious eye damage
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_preservative | - | All cosmetics |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.3–1 | 1 | CIR/Industry |
| Serum | 0.3–1 | 1 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "70445-33-9", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": ">1000", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": …
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "preservative", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "ESSCA; IVDK; NACDG"}
anti_pollution
{"cas_number": "70445-33-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibit…
baby_pediatric
{"cas_number": "70445-33-9", "ingredient_class": "preservative_baby_safe", "pediatric_safety_rating": "good", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Multifunctional, deodorant, booster; generally safe", "transepidermal_absorption_risk_pediatric": "low", "dose_per_kg_body_weight_concern": "Safe at <1%", "skin_surfac…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,combination,normal,acne-prone", "acne_safe": "yes", "source": "Preservative booster"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.5", "product_type": "Toner", "function_at_concentration": "Preservative booster", "source": "CIR Safety Assessment"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "18", "estimated_cost_per_kg_usd_high": "32", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Germany", "bulk_discount_threshold_kg": "200", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Caprylyl Glyc…
deodorant
{"cas_number": "70445-33-9", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "12-24", "odor_reduction_pct": "60-80", "bacteriostatic": "yes", "bactericidal": "no", "target_bacteria": "Staphylococcus/Corynebacterium", "microbiome_impact": "selective", "axillary_microb…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Preservative
Softener and conditioner
Regulatory List Membership (3)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Ethylhexylglycerin.
Regulatory Flags
preservative-booster
multifunctional
antimicrobial
conditioning-agent
hurdle-technology
sensitive-skin-suitable
0.3-0.8pct-dose
preferred-with-phenoxyethanol
membrane-disruptor
eu_children_restricted
ifra_fragrance
Chemical Function
Softener and conditioner
Preservative
Deodorizer
Fragrance
Regulatory Lists
IFRA Transparency
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care - hair styling and care - shampoo
Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. conditions of use are varied from use as a component...
Frequently Asked Questions
Is Ethylhexylglycerin allowed in the EU?
Ethylhexylglycerin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexylglycerin do in cosmetics?
Ethylhexylglycerin functions as: preservative-booster, skin-conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 70445-33-9.
Is Ethylhexylglycerin used outside cosmetics?
Ethylhexylglycerin also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethylhexylglycerin have different safety status in cosmetics vs industrial chemicals?
Ethylhexylglycerin is classified GHS Danger (H318, H332, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Ethylhexylglycerin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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