Is Amodimethicone safe in cosmetics?
Amodimethicone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Amodimethicone
Also known as: Aminofunctional siloxane
INCI: AMODIMETHICONE
Amodimethicone (CAS 68554-54-1) is a cosmetic cosmetic ingredient functioning as hair conditioning, film-forming, anti-static, cuticle repair. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 68554-54-1 →
Auto-generated CPSR Part A draft with source citations
Function
hair conditioning, film-forming, anti-static, cuticle repair
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessed safe for topical use; large molecular weight prevents significant skin absorption; no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amodimethicone.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Amodimethicone, relevant to systemic exposure and MoS calculations.
Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
Variable Da
Log P
5.8
Systemic Absorption
minimal
Topical Bioavailability
0.05-0.2%
Safety Margin Factor
minimal
Source: CIR
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Conditioner | 0.5–3 | 5 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
anti_pollution
{"cas_number": "71750-80-6", "ingredient_class": "anti_pollution", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB…
baby_pediatric
{"cas_number": "71750-80-6", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "12", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Amino-functional - hair", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_concern": "Non-absorbed polymer", "skin_surface_area_to_weight_…
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal", "acne_safe": "yes", "source": "Amino-functional silicone"}
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Leave-in Treatment", "function_at_concentration": "Heat protection, smoothing", "source": "CIR Safety Assessment"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "18", "estimated_cost_per_kg_usd_high": "32", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global", "bulk_discount_threshold_kg": "200", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Dimethicone, Q…
dermal_absorption
{"molecular_weight_da": "Variable", "log_p_value": "5.8", "skin_penetration_level": "surface", "penetration_depth": "surface only", "absorption_pct": "0.1-0.5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "no", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.05-0.2", "safety_margin_factor": "minimal", "source":…
ecotoxicity
{"biodegradable": "no", "biodegradation_days": "1200+", "bioaccumulative": "yes", "aquatic_toxicity_level": "low", "coral_reef_safe": "unknown", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "persistent in water", "soil_toxicity": "accumulates", "endocrine_disruptor": "no", "persistent_organic_pollutant": "yes", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no"…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "o_w", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "trideceth_12,cetrimonium_chloride", "optimal_oil_phase_pct": "10-35", "optimal_water_phase_pct": "65-90", "electrolyte_tolerance": "moderate", "pH_emulsion_stability_range": "3.0-7.0", "viscosity_building_contribution": "moderate", "droplet_size_range_u…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Waterproofing agent
Expert Verdict
Expert safety assessment and concern-level summary for Amodimethicone.
Regulatory Flags
cir-approved
non-volatile-silicone
amino-silicone
heat-protection
hair-buildup-risk
targeted-cuticle-repair
cosmos-prohibited
eu_children_restricted
Known Synonyms
Aminofunctional siloxane
Chemical Function
Waterproofing agent
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Amodimethicone allowed in the EU?
Amodimethicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Amodimethicone do in cosmetics?
Amodimethicone functions as: hair conditioning, film-forming, anti-static, cuticle repair. It is classified as a cosmetic ingredient in our database. CAS number: 68554-54-1.
Compliance Tools
Check Amodimethicone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Browse nearby
Hair Waving Or Straightening
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