Danger GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

3-[(2-Ethylhexyl)oxy]propane-1,2-diol

CAS 70445-33-9

3-[(2-Ethylhexyl)oxy]propane-1,2-diol (CAS 70445-33-9) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H412. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Ethylhexylglycerin →

SOURCE noael studies public
NOAEL studies
5
SOURCE chemical inventory jurisdictions
Regulatory lists
9
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
3-[(2-Ethylhexyl)oxy]propane-1,2-diol
CAS Number
70445-33-9
DTXSID
DTXSID80990652
Molecular Formula
C11H24O3
InChI Key
NCZPCONIKBICGS-UHFFFAOYSA-N
Monoisotopic Mass
204.172545

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Eye Dam. 1; Aquatic Chronic 3H318; H412GHS05Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Softener and conditionerPreservativeDeodorizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies
ValueUnitEndpointRouteSpeciesSource
=0.875mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
147D247K3PUNIIFDA UNII substance identifier--openFDA substances
147D247K3PUNIIFDA UNII substance identifier--openFDA substances
147D247K3PUNIIFDA UNII substance identifier--openFDA substances
147D247K3PUNIIFDA UNII substance identifier--openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered3-(2-ethylhexyloxy)propane-1,2-diol408-080-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. conditions of use are varied from use as a component of aerosol body deodorant or the concentration in products is increased to more than 1%. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
conditioning-agent
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 3-[(2-Ethylhexyl)oxy]propane-1,2-diol?

3-[(2-Ethylhexyl)oxy]propane-1,2-diol (CAS 70445-33-9) is classified under EU CLP Annex VI as Eye Dam. 1; Aquatic Chronic 3 with signal word Danger. Hazard statements: H318; H412. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 3-[(2-Ethylhexyl)oxy]propane-1,2-diol?

3-[(2-Ethylhexyl)oxy]propane-1,2-diol has 5 NOAEL studies in the database. The lowest reported value is 0.875 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 3-[(2-Ethylhexyl)oxy]propane-1,2-diol?

3-[(2-Ethylhexyl)oxy]propane-1,2-diol appears on 6 regulatory/inventory lists including IFRA Transparency, children; Europe; Personal care - general moisturizing - hand/body lotion, children; Europe; Personal care - hair styling and care - shampoo, and 3 more. Source: EPA CPDat.

Is 3-[(2-Ethylhexyl)oxy]propane-1,2-diol used in cosmetics?

Yes, 3-[(2-Ethylhexyl)oxy]propane-1,2-diol is also indexed as a cosmetic ingredient under the name Ethylhexylglycerin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-[(2-Ethylhexyl)oxy]propane-1,2-diol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 3-[(2-Ethylhexyl)oxy]propane-1,2-diol have different safety status in cosmetics vs industrial chemicals?

3-[(2-Ethylhexyl)oxy]propane-1,2-diol is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics.

Is 3-[(2-Ethylhexyl)oxy]propane-1,2-diol used outside industrial chemicals?

3-[(2-Ethylhexyl)oxy]propane-1,2-diol also appears in cosmetics databases.