Is ETHOXYDIGLYCOL ACETATE safe in cosmetics?
ETHOXYDIGLYCOL ACETATE has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
ETHOXYDIGLYCOL ACETATE
Also known as: Ethanol, 2-(2-ethoxyethoxy)-, acetate, Diethylene glycol monoethyl ether acetate, Ethanol, 2-(2-ethoxyethoxy)-, 1-acetate, Acetic acid 2-(2-ethoxyethoxy)ethyl ester, BRN 1764643 (+9 more)
ETHOXYDIGLYCOL ACETATE (CAS 112-15-2) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =167 mg/kg bw/day in Pig (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 112-15-2 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
2-(2-ethoxyethoxy)ethyl acetate
InChIKey
FPZWZCWUIYYYBU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for ETHOXYDIGLYCOL ACETATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =167 mg/kg bw/day | oral | Pig | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for ETHOXYDIGLYCOL ACETATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ETHOXYDIGLYCOL ACETATE by CAS number or substance name.
Studies
3
Lowest NOAEL
167 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Ethanol, 2-(2-ethoxyethoxy)-, acetate
Diethylene glycol monoethyl ether acetate
Ethanol, 2-(2-ethoxyethoxy)-, 1-acetate
Acetic acid 2-(2-ethoxyethoxy)ethyl ester
BRN 1764643
Carbitol acetate
Diethylene glycol ethyl ether acetate
Diglycol monoethyl ether acetate
EINECS 203-940-1
Ektasolve de acetate
Glycol ether de acetate
NSC 8702
2-(2-Ethoxyethoxy)ethylester kyseliny octove
Karbitolacetat
Chemical Function
Solvent
Film former
Regulatory Lists
artificial_sweat; detected; emissions; Europe; Toys and children's products
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185106
Frequently Asked Questions
Is ETHOXYDIGLYCOL ACETATE allowed in the EU?
ETHOXYDIGLYCOL ACETATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ETHOXYDIGLYCOL ACETATE do in cosmetics?
ETHOXYDIGLYCOL ACETATE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-15-2.
What is the NOAEL for ETHOXYDIGLYCOL ACETATE?
The NOAEL (No Observed Adverse Effect Level) for ETHOXYDIGLYCOL ACETATE is =167 mg/kg bw/day based on a reproduction developmental study via oral route in Pig. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is ETHOXYDIGLYCOL ACETATE used outside cosmetics?
ETHOXYDIGLYCOL ACETATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ETHOXYDIGLYCOL ACETATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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