Good Cosmetic Ingredient NOAEL Data

Ethylacetoacetate Ethylene Glycol Ketal

Also known as: 5-19-07-00231, BRN 0130164, EINECS 229-114-0, Ethyl acetoacetate 3-ethylene acetal, Ethyl acetoacetate ethylene glycol ketal (+7 more)

INCI: ETHYLACETOACETATE ETHYLENE GLYCOL KETAL

Ethylacetoacetate Ethylene Glycol Ketal (CAS 6413-10-1) is a cosmetic cosmetic ingredient functioning as Fragrance with fresh, apple-like aroma. Reported NOAEL =1000 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.

View industrial chemical safety profile for CAS 6413-10-1 →

Auto-generated CPSR Part A draft with source citations

CAS Number

6413-10-1

View industrial chemical safety profile →

Function

Fragrance with fresh, apple-like aroma

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C8H14O4

174.19 g/mol

EC Number

229-114-0

PubChem CID

80865

IUPAC Name

ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

InChIKey

XWEOGMYZFCHQNT-UHFFFAOYSA-N

UNII: G5EXI4NID0 Wikidata: Q1879409

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes Permitted — FEMA No. 4477; FEMA GRAS (Publication 24); JECFA Flavor No. 1969

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylacetoacetate Ethylene Glycol Ketal.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Ethylacetoacetate Ethylene Glycol Ketal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=1000 mg/kg bw/day	oral	Rat	developmental	ECHA

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

NESIL

581 µg/cm²

GHS: 1B Human: positive

Source: HPPT: [687] Epstein WL (1978): Report to RIFM, 7 November, unpublished.

HRIPT Human Patch Test Studies

4 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	5400	-	-
HMT	-	13500	-	-
HRIPT	-	581	-	-
HRIPT	-	11628	-	-

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (2)

JECFA Number

1969

Source: WHO/JECFA

JECFA Evaluation

ETHYL ACETOACETATE ETHYLENEGLYCOL KETAL | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/71

Source: WHO/JECFA

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Flavouring and nutrient Fragrance

Regulatory List Membership (3)

IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS) Consumer Product Chemical

Expert Verdict

Expert safety assessment and concern-level summary for Ethylacetoacetate Ethylene Glycol Ketal.

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Ethylacetoacetate Ethylene Glycol Ketal by CAS number or substance name.

Studies

Lowest NOAEL

1000 mg/kg bw/day

Highest NOAEL

1000 mg/kg bw/day

ECHA

Known Synonyms

5-19-07-00231 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0

Chemical Function

Fragrance

Regulatory Lists

IFRA Transparency food_additive; Substances Added to Food (formerly EAFUS) (2/2019) consumer_product

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in food safety data.

SOURCE EFSA / FDA GRAS food_additives

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name

ETHYL ACETOACETATE ETHYLENEGLYCOL KETAL

ADI

No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

Food Category

flavoring

View full food safety profile →

Frequently Asked Questions

Is Ethylacetoacetate Ethylene Glycol Ketal safe in cosmetics?

Ethylacetoacetate Ethylene Glycol Ketal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Ethylacetoacetate Ethylene Glycol Ketal allowed in the EU?

Ethylacetoacetate Ethylene Glycol Ketal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylacetoacetate Ethylene Glycol Ketal do in cosmetics?

Ethylacetoacetate Ethylene Glycol Ketal functions as: Fragrance with fresh, apple-like aroma. It is classified as a cosmetic ingredient in our database. CAS number: 6413-10-1.

What is the NOAEL for Ethylacetoacetate Ethylene Glycol Ketal?

The NOAEL (No Observed Adverse Effect Level) for Ethylacetoacetate Ethylene Glycol Ketal is =1000 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ECHA.

Is Ethylacetoacetate Ethylene Glycol Ketal used outside cosmetics?

Ethylacetoacetate Ethylene Glycol Ketal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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