Also known as: 5-19-07-00231, BRN 0130164, EINECS 229-114-0, Ethyl acetoacetate 3-ethylene acetal, Ethyl acetoacetate ethylene glycol ketal (+7 more)
CAS 6413-10-1
1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester (CAS 6413-10-1) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Ethylacetoacetate Ethylene Glycol Ketal →
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =23.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| G5EXI4NID0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5EXI4NID0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5EXI4NID0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5EXI4NID0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 581 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 11628 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 2-methyl-1,3-dioxolane-2-acetate | 229-114-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester has 14 NOAEL studies in the database. The lowest reported value is 23.5 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product. Source: EPA CPDat.
Yes, 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester is also indexed as a cosmetic ingredient under the name Ethylacetoacetate Ethylene Glycol Ketal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester also appears in cosmetics, food safety databases.