NOAEL Studies Cosmetic Ingredient

Ethylacetoacetate Ethylene Glycol Ketal NOAEL Studies

INCI: ETHYLACETOACETATE ETHYLENE GLYCOL KETAL

CAS: 6413-10-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8904; row=6208; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester; preferred_name=1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester; dtxsid=DTXSID3041241; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241; source_file=acute_oral.xlsx
NTP ICE skin sensitization 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9212; Record_ID=skin_sensitization_invivo_2038; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90158-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Induction dose per skin area 581 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9226; Record_ID=skin_sensitization_invivo_2042; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=581; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31220538; 10.1016/j.fct.2019.110590; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Induction dose per skin area 5400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9210; Record_ID=skin_sensitization_invivo_2038; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90158-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Induction dose per skin area 11628 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9234; Record_ID=skin_sensitization_invivo_2043; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=11628; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31220538; 10.1016/j.fct.2019.110590; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Induction dose per skin area 13500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9218; Record_ID=skin_sensitization_invivo_2040; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=13500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1979: report to RIFM|RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90158-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9216; Record_ID=skin_sensitization_invivo_2038; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90158-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
NTP ICE skin sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9233; Record_ID=skin_sensitization_invivo_2042; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID3041241; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31220538; 10.1016/j.fct.2019.110590; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041241
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be56e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/9998/7/9/3?documentUUID=a9c873b9-4ffc-48dd-b028-c155cf0c6c8b; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15820583:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15a8214bfc17600324a47c484ade7f94
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =23.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631920:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09f21ae34471cb82e12ab699afb25692
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier G5EXI4NID0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G5EXI4NID0"}
openFDA substances FDA UNII substance identifier G5EXI4NID0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G5EXI4NID0"}
openFDA substances FDA UNII substance identifier G5EXI4NID0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G5EXI4NID0"}
openFDA substances FDA UNII substance identifier G5EXI4NID0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G5EXI4NID0"}