Is Ethyl Valerate safe in cosmetics?
Ethyl Valerate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Ethyl Valerate
Also known as: EINECS 208-726-1, Ethyl valerianate, FEMA No. 2462, UNII-95R258T4P6, FEMA 2462 (+2 more)
INCI: ETHYL VALERATE
Ethyl Valerate (CAS 539-82-2) is a cosmetic cosmetic ingredient functioning as Fragrance. Reported NOAEL =120 mg/kg bw/day in Rat (EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 539-82-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
ethyl pentanoate
InChIKey
ICMAFTSLXCXHRK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no 21 CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Valerate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Ethyl Valerate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =120 mg/kg bw/day | oral: drinking water | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| NOAEL | =120 mg/kg bw/day | oral: drinking water | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
30
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL PENTANOATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL VALERATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Valerate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Valerate by CAS number or substance name.
Studies
2
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
120 mg/kg bw/day
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
Known Synonyms
EINECS 208-726-1
Ethyl valerianate
FEMA No. 2462
UNII-95R258T4P6
FEMA 2462
N-Valeric acid ethyl ester
Valeric acid, ethyl ester (8CI)
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL47483
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ETHYL VALERATE
Food Category
flavoring
Frequently Asked Questions
Is Ethyl Valerate allowed in the EU?
Ethyl Valerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Valerate do in cosmetics?
Ethyl Valerate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 539-82-2.
What is the NOAEL for Ethyl Valerate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Valerate is =120 mg/kg bw/day based on a subchronic study via oral: drinking water route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
Is Ethyl Valerate used outside cosmetics?
Ethyl Valerate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Valerate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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