Is Hordenine safe in cosmetics?
Hordenine has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Hordenine
Also known as: EINECS 208-710-4, UNII-K3489CA082, 4-[2-(Dimethylamino)ethyl]phenol, N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamine, N,N-Dimethyl-4-hydroxy-beta-phenethylamine (+2 more)
INCI: HORDENINE
Hordenine (CAS 539-15-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (phenethylamine alkaloid from barley). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 539-15-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (phenethylamine alkaloid from barley)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-[2-(dimethylamino)ethyl]phenol
InChIKey
KUBCEEMXQZUPDQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hordenine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Hordenine.
Regulatory Flags
potential-allergen
Known Synonyms
EINECS 208-710-4
UNII-K3489CA082
4-[2-(Dimethylamino)ethyl]phenol
N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamine
N,N-Dimethyl-4-hydroxy-beta-phenethylamine
N,N-Dimethyltyramine
p-(2-Dimethylaminoethyl)phenol
Chemical Function
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HORDENINE
ChEMBL ID
CHEMBL505789
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Hordenine
Food Category
sports_nutrition
Frequently Asked Questions
Is Hordenine allowed in the EU?
Hordenine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hordenine do in cosmetics?
Hordenine functions as: Skin conditioning agent (phenethylamine alkaloid from barley). It is classified as a cosmetic ingredient in our database. CAS number: 539-15-1.
Is Hordenine used outside cosmetics?
Hordenine also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hordenine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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