Is Ethyl Methacrylate safe in cosmetics?
Ethyl Methacrylate has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Ethyl Methacrylate
Also known as: 2-Propenoic acid, 2-methyl-, ethyl ester, 4-02-00-01523, BRN 0471201, EINECS 202-597-5, Ethyl 2-methacrylate (+6 more)
INCI: ETHYL METHACRYLATE
Ethyl Methacrylate (CAS 97-63-2) is a cosmetic cosmetic ingredient functioning as Film-forming agent for artificial nail systems. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-63-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethyl Methacrylate is classified GHS Danger (H225, H315, H317, H319, H335, H332) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film-forming agent for artificial nail systems
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
ethyl 2-methylprop-2-enoate
InChIKey
SUPCQIBBMFXVTL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
FDA has issued guidance and warnings on methacrylate-containing nail products. Not banned under 21 CFR but subject to adverse event monitoring.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
Lachrymation. The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Methacrylate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H225 Highly flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | restricted | No concentration limit stated | All nail products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0272
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapors are irritating to eyes and respiratory system. | A skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Viscosity modifier
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Methacrylate.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Methacrylate by CAS number or substance name.
Studies
18
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
2400 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Propenoic acid, 2-methyl-, ethyl ester
4-02-00-01523
BRN 0471201
EINECS 202-597-5
Ethyl 2-methacrylate
Ethyl alpha-methylacrylate
2-Methylacrylic acid, ethyl ester
RCRA waste number U118
Rhoplex AC-33
Ethylester kyseliny methakrylove
UNII-80F70CLT4O
Chemical Function
Viscosity modifier
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Europe; Personal care - nails
detected; Europe; Personal care - nails - nail polish
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182984
Frequently Asked Questions
Is Ethyl Methacrylate allowed in the EU?
Ethyl Methacrylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Methacrylate do in cosmetics?
Ethyl Methacrylate functions as: Film-forming agent for artificial nail systems. It is classified as a cosmetic ingredient in our database. CAS number: 97-63-2.
Is Ethyl Methacrylate used outside cosmetics?
Ethyl Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethyl Methacrylate have different safety status in cosmetics vs industrial chemicals?
Ethyl Methacrylate is classified GHS Danger (H225, H315, H317, H319, H335, H332) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Ethyl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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