Also known as: 2-Propenoic acid, 2-methyl-, ethyl ester, 4-02-00-01523, BRN 0471201, EINECS 202-597-5, Ethyl 2-methacrylate (+6 more)
CAS 97-63-2
Ethyl methacrylate (CAS 97-63-2) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H335; H315; H319; H317. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Ethyl methacrylate is classified GHS Danger (H225, H335, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 | H225; H335; H315; H319; H317 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care - nails | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =854 | mg/m3 | BMCL (HEC) | inhalation | Rat | ToxValDB_PPRTV_(CPHEA) |
| =267 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =370.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 80F70CLT4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80F70CLT4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80F70CLT4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80F70CLT4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 38.7242 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 55 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =14800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =84032.8 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =0.3 | mg/m3 | RfC | inhalation | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
| =3 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.01 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =0.09 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
Showing 15 of 15 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl methacrylate | 202-597-5 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Ethyl methacrylate (CAS 97-63-2) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Danger. Hazard statements: H225; H335; H315; H319; H317. Source: EU CLP Annex VI (ECHA).
Ethyl methacrylate has 15 NOAEL studies in the database. The lowest reported value is 267 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Ethyl methacrylate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), Europe; Personal care - nails, and 3 more. Source: EPA CPDat.
Yes, Ethyl methacrylate is also indexed as a cosmetic ingredient under the name Ethyl Methacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Ethyl methacrylate is classified GHS Danger (H225, H335, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics.
Ethyl methacrylate also appears in cosmetics, pharmaceutical, cannabis databases.