Also known as: alpha,alpha-Dimethylphenethyl acetate, Benzeneethanol, .alpha.,.alpha.-dimethyl-, 1-acetate, Benzeneethanol, alpha,alpha-dimethyl-, 1-acetate, Benzyl dimethyl carbinyl acetate, Benzyldimethyl carbinyl acetate (+11 more)
INCI: DIMETHYL BENZYL CARBINYL ACETATE
Dimethylbenzyl Carbinyl Acetate (DMBCA) (CAS 151-05-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with sweet, floral-fruity, rose-jasmine notes. Reported NOAEL =360 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylbenzyl Carbinyl Acetate (DMBCA).
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Toxicological Studies
2 study endpoints found for Dimethylbenzyl Carbinyl Acetate (DMBCA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=360 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
NOAEL
=1000 mg/kg bw/day
oral
Rat
developmental
ToxValDB_ECHA_IUCLID
Sensitization Profile
Contact sensitization data for Dimethylbenzyl Carbinyl Acetate (DMBCA) based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS/1459/11
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
775 µg/cm²
GHS: 1BHuman: positive
Source: HPPT: [151] Kligman AM (1971): Report to RIFM, 2 April, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
Test Type
N
Sensitized
Dose µg/cm²
NESIL µg/cm²
Potency
HRIPT
107
0
1181
1181
non-sensitizer
HMT
-
0
2592
-
-
HMT
-
0
2592
-
-
HMT
-
0
2592
-
-
HRIPT
-
0
775
-
-
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (6)
JECFA Number
1655
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-BENZYL-2-PROPYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYL DIMETHYL CARBINYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIMETHYL BENZYL CARBINYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYL-1-PHENYL-2-PROPYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrientFragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency ListEPA Safer Chemical Ingredients List (SCIL)FDA Substances Added to Food (EAFUS)Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dimethylbenzyl Carbinyl Acetate (DMBCA).
Is Dimethylbenzyl Carbinyl Acetate (DMBCA) safe in cosmetics?
Dimethylbenzyl Carbinyl Acetate (DMBCA) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Is Dimethylbenzyl Carbinyl Acetate (DMBCA) allowed in the EU?
Dimethylbenzyl Carbinyl Acetate (DMBCA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylbenzyl Carbinyl Acetate (DMBCA) do in cosmetics?
Dimethylbenzyl Carbinyl Acetate (DMBCA) functions as: Fragrance ingredient with sweet, floral-fruity, rose-jasmine notes. It is classified as a cosmetic ingredient in our database. CAS number: 151-05-3.
What is the NOAEL for Dimethylbenzyl Carbinyl Acetate (DMBCA)?
The NOAEL (No Observed Adverse Effect Level) for Dimethylbenzyl Carbinyl Acetate (DMBCA) is =360 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Dimethylbenzyl Carbinyl Acetate (DMBCA) used outside cosmetics?
Dimethylbenzyl Carbinyl Acetate (DMBCA) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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