Is Aziridine safe in cosmetics?
Aziridine has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: prohibited.
Aziridine
Also known as: 5-20-01-00003, 1H-Azirine, dihydro-, BRN 0102380, Dihydroazirene, Dihydroazirine (+7 more)
INCI: AZIRIDINE (SYNONYM: ETHYLENIMINE)
Aziridine (CAS 151-56-4) is a cosmetic cosmetic ingredient functioning as None in cosmetics - industrial chemical monomer/intermediate. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 151-56-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aziridine is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H300, H310, H330, H314, H318, H340, H350).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
None in cosmetics - industrial chemical monomer/intermediate
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
aziridine
InChIKey
NOWKCMXCCJGMRR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Prohibited - classified as a known carcinogen (IARC Group 2B; NTP reasonably anticipated); not permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aziridine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. The substance may cause effects on the central nervous system, kidneys and liver. Exposure far above the OEL could cause death. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
9, Sup 7, 71
Evaluation Year
1998
NB Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHealth HazardAcute ToxicityCorrosiveEnvironmental Hazard
Hazard Class and Category
Flam. Liq. 2; Carc. 1B; Muta. 1B; Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Chronic 2
Hazard Statements
- H225 Highly flammable liquid and vapour
- H350 May cause cancer
- H340 May cause genetic defects
- H330 Fatal if inhaled
- H310 Fatal in contact with skin
- H300 Fatal if swallowed
- H314 Causes severe skin burns and eye damage
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 733
(EC) 2009/1223
CMR: Carcinogenic Cat. 1B(),Mutagenic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 733
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Aziridine | Group 2B: Possibly carcinogenic to humans | Volume 9: (1975) Some Aziridines, N-, S- and O-Mustards and Selenium | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3) |
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of aziridine were available. There is limited evidence in experimental animals for the carcinogenicity of aziridine. Overall Evaluation: Aziridine is possibly carcinogenic to humans (Group 2B). In making the overall evaluation, the Working Group took into consideration that aziridine is a direct acting alkylating agent which is mu
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0100
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritation of eyes and nose: 100 ppm | May be fatal if absorbed through skin or inhaled. Corrosive. Causes severe eye, & skin burns.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
ETHYLENIMINE | 1986 | The Committee concluded that ethylenimine is a genotoxic carcinogen in the livers and lungs of mice; no ADI was established for this compound. Use of polyethylenimine as an immobilizing agent in the production of immobilized enzyme preparations was considered acceptable on condition that the amount of ethylenimine migrating into food from the immobilized enzyme preparations i
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
No specific technical function
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Aziridine.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
5-20-01-00003
1H-Azirine, dihydro-
BRN 0102380
Dihydroazirene
Dihydroazirine
EINECS 205-793-9
RCRA waste number P054
Ethyleenimine
Etilenimina
UNII-54P5FEX9FH
EI
dimethyleneimine
Chemical Function
Chemical reaction regulator
No specific technical function
Regulatory Lists
banned; Europe; Personal care
drinking_water; Europe; manufacturing; plastic_additive
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Indirect additives food contact (10/2018)
Europe; Food contact items; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AZIRIDINE
ChEMBL ID
CHEMBL540990
Frequently Asked Questions
Is Aziridine allowed in the EU?
Aziridine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Aziridine do in cosmetics?
Aziridine functions as: None in cosmetics - industrial chemical monomer/intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 151-56-4.
Is Aziridine used outside cosmetics?
Aziridine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aziridine have different safety status in cosmetics vs industrial chemicals?
Aziridine is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H300, H310, H330, H314, H318, H340, H350).
Compliance Tools
Check Aziridine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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