NOAEL Studies
Cosmetic Ingredient
Dimethylbenzyl Carbinyl Acetate (DMBCA) NOAEL Studies
INCI: DIMETHYL BENZYL CARBINYL ACETATE
CAS: 151-05-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =3300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2922; row=6257; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethylbenzylcarbinyl acetate; preferred_name=Dimethylbenzylcarbinyl acetate; dtxsid=DTXSID3041877; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8344; RecordID=ARPathway2016_884; DatasetName=ARPathway2016; DTXSID=DTXSID3041877; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877 |
NTP_ICE_skin_sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5649; Record_ID=skin_sensitization_invivo_1306; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041877; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90074-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5648; Record_ID=skin_sensitization_invivo_1306; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041877; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90074-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 775 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5660; Record_ID=skin_sensitization_invivo_1309; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041877; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22445843; 10.1016/j.fct.2012.02.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5651; Record_ID=skin_sensitization_invivo_1306; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041877; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90074-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041877 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6da; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19336/7/9/3?documentUUID=bcc09c7d-d034-48aa-8408-93ee4b8ca53a; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821868:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7eed6ccb3e12f607401dbbf2b50830f2 |
| ToxValDB_ECHA_IUCLID | NOAEL | =360 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7ee4b0a7c65d1c473e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19336/7/6/2?documentUUID=bcc09c7d-d034-48aa-8408-93ee4b8ca53a; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15835307:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5de4dd3839713881a17b92c1cb65336d |
| ToxValDB_ECHA_IUCLID | NOAEL | ~500 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7ee4b0a7c65d1c4742; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19336/7/6/2?documentUUID=bcc09c7d-d034-48aa-8408-93ee4b8ca53a; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15838807:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6be43ac959952877580ede1e50e2b329 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =12.695 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631450:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a043fba4819a5e51a23f206903847578 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6Y9488RL8H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6Y9488RL8H"} |
| openFDA substances | FDA UNII substance identifier | 6Y9488RL8H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6Y9488RL8H"} |
| openFDA substances | FDA UNII substance identifier | 6Y9488RL8H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6Y9488RL8H"} |
| openFDA substances | FDA UNII substance identifier | 6Y9488RL8H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6Y9488RL8H"} |