Is DIMETHYL MALONATE safe in cosmetics?
DIMETHYL MALONATE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
DIMETHYL MALONATE
Also known as: Propanedioic acid, dimethyl ester, 1,3-Dimethyl propanedioate, EINECS 203-597-8, UNII-EM8Y79998C
DIMETHYL MALONATE (CAS 108-59-8) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-59-8 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
dimethyl propanedioate
InChIKey
BEPAFCGSDWSTEL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for DIMETHYL MALONATE across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for DIMETHYL MALONATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DIMETHYL MALONATE by CAS number or substance name.
Studies
6
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Propanedioic acid, dimethyl ester
1,3-Dimethyl propanedioate
EINECS 203-597-8
UNII-EM8Y79998C
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1986332
Frequently Asked Questions
Is DIMETHYL MALONATE allowed in the EU?
DIMETHYL MALONATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DIMETHYL MALONATE do in cosmetics?
DIMETHYL MALONATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 108-59-8.
Is DIMETHYL MALONATE used outside cosmetics?
DIMETHYL MALONATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check DIMETHYL MALONATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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