NOAEL Studies Cosmetic Ingredient

DIMETHYL MALONATE NOAEL Studies

CAS: 108-59-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =5331 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_748; row=7451; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl malonate; preferred_name=Dimethyl malonate; dtxsid=DTXSID4029145; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029145; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8246; RecordID=ARPathway2016_514; DatasetName=ARPathway2016; DTXSID=DTXSID4029145; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029145
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3366; Record_ID=skin_sensitization_invivo_851; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029145; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029145
NTP_ICE_skin_sensitization Induction dose per skin area 5400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3364; Record_ID=skin_sensitization_invivo_851; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029145; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029145
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3370; Record_ID=skin_sensitization_invivo_851; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029145; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029145
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL =300 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de8e4b0a676289de5b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Histopathology: Liver: Hypertrophy, hepatocyte; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=HESS:15638492:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fde101c2006ca4cbc66eac7fb0deaedf
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier EM8Y79998C UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8Y79998C"}
openFDA substances FDA UNII substance identifier EM8Y79998C UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8Y79998C"}
openFDA substances FDA UNII substance identifier EM8Y79998C UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8Y79998C"}
openFDA substances FDA UNII substance identifier EM8Y79998C UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8Y79998C"}