NOAEL Studies Cosmetic Ingredient

Dihydrocoumarin NOAEL Studies

INCI: DIHYDROCOUMARIN

CAS: 119-84-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 110 mg/kg bw/day rat oral 84 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 150 mg/kg bw/day dog oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 200 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 580 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 600 mg/kg bw/day rat oral 270 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1500 mg/kg bw/day rat oral 16 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2250 mg/kg bw/day mouse oral 16 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =150 mg/kg bw/day Rat - 91 days subchronic EFSA AFC - 2008 - OutputID 2300 - Flavouring Group Evaluation 80 (FGE.80). Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) - doi:10.2903/j.efsa.2008.919
EFSA NOAEL =300 mg/kg bw/day Rat oral: gavage 730 days chronic/long term toxicity EFSA AFC - 2008 - OutputID 2300 - Flavouring Group Evaluation 80 (FGE.80). Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) - doi:10.2903/j.efsa.2008.919
EFSA NOAEL =150 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2622.; TITLE=Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2622; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15614071_15614072_15614074:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be4b993910c225f2ec0a272ea3d65db1
EFSA NOAEL =300 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA AFC (2008). Flavouring Group Evaluation 80 (FGE.80). Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC). doi:10.2903/j.efsa.2008.919.; TITLE=Flavouring Group Evaluation 80 (FGE.80). Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2008.919; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=EFSA_dup_-_15614073_15614075:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d10bc6675cb63c06d5dabea1c192f6d1
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1460 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1543; row=3793; data_type=In Vivo; mixture=Chemical; chemical_name=3,4-Dihydrocoumarin; preferred_name=3,4-Dihydrocoumarin; dtxsid=DTXSID2020474; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020474; source_file=acute_oral.xlsx
NTP ICE cancer 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer POLY-3 lowest dose 400 mg/kg bw/day Mouse Gavage - In Vivo; Two year cancer bioassay sheet=Data; excel_row=2371; Record_ID=cancer_6004; Data_Type=In Vivo; Formulation_Name=3,4-Dihydrocoumarin; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=400; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-423; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr423/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE cancer POLY-3 lowest dose 600 mg/kg bw/day Rat Gavage - In Vivo; Two year cancer bioassay sheet=Data; excel_row=2368; Record_ID=cancer_6003; Data_Type=In Vivo; Formulation_Name=3,4-Dihydrocoumarin; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=600; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Level_of_Evidence=Some evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Adenoma; Reference=TR-423; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr423/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE cancer Top dose 600 mg/kg Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=2361; Record_ID=cancer_6006; Data_Type=In Vivo; Formulation_Name=3,4-Dihydrocoumarin; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=600; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-423; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr423/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE cancer Top dose 800 mg/kg Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=2364; Record_ID=cancer_6001; Data_Type=In Vivo; Formulation_Name=3,4-Dihydrocoumarin; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=800; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-423; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr423/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 531.7 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3651; Record_ID=skin_sensitization_invitro_836; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=531.70000000000005; Reported_Response_Unit=ug/mL; Response=531.7; Response_Unit=ug/mL; Reference=Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization CD86, EC150 >1037.127 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8242; Record_ID=skin_sensitization_invitro_2265; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=148.161; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1037.127; Converted_Response_Unit=ug/mL; Response=1037.127; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization CV75 810 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3653; Record_ID=skin_sensitization_invitro_836; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=h-CLAT; Endpoint=CV75; Reported_Response=810; Reported_Response_Unit=ug/mL; Response=810; Response_Unit=ug/mL; Reference=Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4172; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 1.9375 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4189; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.9375; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Concentration, one positive response 0.625 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4185; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.625; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Concentration, one positive response 0.8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4168; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.8; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Depletion Cys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1351; Record_ID=skin_sensitization_invitro_362; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Depletion Lys 39.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1349; Record_ID=skin_sensitization_invitro_362; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=39.700000000000003; Reported_Response_Unit=%; Response=39.7; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Depletion Lys + Cys 19.85 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1352; Record_ID=skin_sensitization_invitro_362; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=19.850000000000001; Reported_Response_Unit=%; Response=19.85; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization EC1.5 >2000 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4927; Record_ID=skin_sensitization_invitro_1140; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization EC3 3.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13103; Record_ID=skin_sensitization_invivo_3101; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=LLNA; Endpoint=EC3; Response=3.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Vocanson et al. 2006; 16685137; 10.1159/000093248; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization EC3 5.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13102; Record_ID=skin_sensitization_invivo_3100; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=LLNA; Endpoint=EC3; Response=5.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Imax 1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4931; Record_ID=skin_sensitization_invitro_1140; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1; Reported_Response_Unit=Unitless; Response=1; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Incidence of positive responses 51.61 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4180; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=51.61; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Incidence of positive responses 100 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4164; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=100; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area 12960 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4162; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12960; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area 14170 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4178; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=14170; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 648 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4174; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 1373 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4191; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1373; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area, one positive response 442.9 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4187; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=442.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Induction dose per skin area, one positive response 518.4 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4170; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=518.4; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4193; Record_ID=skin_sensitization_invivo_1014; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4177; Record_ID=skin_sensitization_invivo_1011; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2020474; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90068-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020474; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020474
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =10 % Mouse dermal short-term; 16 days short-term LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604563:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=abecc2cd6e80a71d54ae89a01827ccb0
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL <75 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df8e4b0a676289deba8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Body Weight Changes: decrease|Hematology: Plt decrease, Hct decrease, Hgb decrease, RBC decrease, WBC decrease, Lympho decrease|Blood Chemistry: Alb increase, Ch E decrease, BUN increase, TP increase, increase, SDH increase|Absolute Organ Weight: Right kidney increase, Liver increase|Relative Organ Weight: Right kidney increase, Liver increase|Histopathology: Liver/centrilobular-Hepatocellular hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|mortality/survival|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638273:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f00b40e721df3c4fe2b34b58c2bc50dd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier NM5K1Y1BT2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NM5K1Y1BT2"}
openFDA substances FDA UNII substance identifier NM5K1Y1BT2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NM5K1Y1BT2"}
openFDA substances FDA UNII substance identifier NM5K1Y1BT2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NM5K1Y1BT2"}
openFDA substances FDA UNII substance identifier NM5K1Y1BT2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NM5K1Y1BT2"}