Is DIETHYLHEXYLAMINE safe in cosmetics?
DIETHYLHEXYLAMINE has a safety rating of "MODERATE" in our database. EU status: restricted. 2 toxicological study endpoint(s) are available in our database.
DIETHYLHEXYLAMINE
Also known as: 2,2'-Diethylhexylamine, 2,2'-Diethyldihexylamine, Di(2-ethylhexyl)amine, N,N-Bis(2-ethylhexyl)amine, N,N-Di(2-ethylhexyl)amine (+6 more)
DIETHYLHEXYLAMINE (CAS 106-20-7) is a cosmetic cosmetic ingredient functioning as Antistatic. Reported NOAEL =30 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max II/411. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-20-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DIETHYLHEXYLAMINE is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is restricted in EU cosmetics at max II/411.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-ethyl-N-(2-ethylhexyl)hexan-1-amine
InChIKey
SAIKULLUBZKPDA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/411
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for DIETHYLHEXYLAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =75 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for DIETHYLHEXYLAMINE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DIETHYLHEXYLAMINE by CAS number or substance name.
Studies
2
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
75 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,2'-Diethylhexylamine
2,2'-Diethyldihexylamine
Di(2-ethylhexyl)amine
N,N-Bis(2-ethylhexyl)amine
N,N-Di(2-ethylhexyl)amine
1-Hexanamine, 2-ethyl-N-(2-ethylhexyl)-
Bis-2-ethylhexylamine
BRN 1748342
EINECS 203-372-4
NSC 5329
UNII-9U5Q5UV6DB
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1330355
Frequently Asked Questions
Is DIETHYLHEXYLAMINE allowed in the EU?
DIETHYLHEXYLAMINE EU regulatory status: restricted. Maximum allowed concentration: II/411. This is based on EU Regulation 1223/2009 and its amendments.
What does DIETHYLHEXYLAMINE do in cosmetics?
DIETHYLHEXYLAMINE functions as: Antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 106-20-7.
What is the NOAEL for DIETHYLHEXYLAMINE?
The NOAEL (No Observed Adverse Effect Level) for DIETHYLHEXYLAMINE is =30 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is DIETHYLHEXYLAMINE used outside cosmetics?
DIETHYLHEXYLAMINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DIETHYLHEXYLAMINE have different safety status in cosmetics vs industrial chemicals?
DIETHYLHEXYLAMINE is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is restricted in EU cosmetics at max II/411.
Compliance Tools
Check DIETHYLHEXYLAMINE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
1,2,6-Hexanetriol
Good
Chemical family
Humectant, solvent, viscosity control...
BUTENE
Good
Chemical family
Not Reported
Butadiene
Poor
Chemical family
Industrial monomer; not intended for ...
Is DIETHYLHEXYLAMINE in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for DIETHYLHEXYLAMINE in your formulation.