What is the NOAEL for Bis-2-ethylhexylamine?
Bis-2-ethylhexylamine has 13 NOAEL studies in the database. The lowest reported value is 1.76 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Bis-2-ethylhexylamine
Also known as: 2,2'-Diethylhexylamine, 2,2'-Diethyldihexylamine, Di(2-ethylhexyl)amine, N,N-Bis(2-ethylhexyl)amine, N,N-Di(2-ethylhexyl)amine (+5 more)
CAS 106-20-7
Bis-2-ethylhexylamine (CAS 106-20-7) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, ECHA REACH.
View cosmetic safety profile for Diethylhexylamine (Di-2-ethylhexylamine) →
Cross-Vertical Regulatory Divergence
Bis-2-ethylhexylamine is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Bis-2-ethylhexylamine
CAS Number
106-20-7
DTXSID
DTXSID7025053
Molecular Formula
C16H35N
InChI Key
SAIKULLUBZKPDA-UHFFFAOYSA-N
Monoisotopic Mass
241.27695
Synonyms
2,2'-Diethylhexylamine2,2'-DiethyldihexylamineDi(2-ethylhexyl)amineN,N-Bis(2-ethylhexyl)amineN,N-Di(2-ethylhexyl)amine1-Hexanamine, 2-ethyl-N-(2-ethylhexyl)-BRN 1748342EINECS 203-372-4NSC 5329UNII-9U5Q5UV6DB
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.76 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9U5Q5UV6DB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9U5Q5UV6DB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9U5Q5UV6DB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9U5Q5UV6DB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.91 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1640 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =43.7 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =116 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =200 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1412 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =75 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis(2-ethylhexyl)amine | 203-372-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1330355
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
Is Bis-2-ethylhexylamine used in cosmetics?
Yes, Bis-2-ethylhexylamine is also indexed as a cosmetic ingredient under the name Diethylhexylamine (Di-2-ethylhexylamine). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bis-2-ethylhexylamine come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Bis-2-ethylhexylamine have different safety status in cosmetics vs industrial chemicals?
Bis-2-ethylhexylamine is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is allowed in EU cosmetics.
Is Bis-2-ethylhexylamine used outside industrial chemicals?
Bis-2-ethylhexylamine also appears in cosmetics, pharmaceutical databases.