Is Chrysin safe in cosmetics?
Chrysin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Chrysin
Also known as: 5-18-04-00076, BRN 0233276, 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one, EINECS 207-549-7, UNII-3CN01F5ZJ5 (+1 more)
INCI: CHRYSIN
Chrysin (CAS 480-40-0) is a cosmetic active ingredient functioning as Skin-brightening active; flavonoid antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 480-40-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-brightening active; flavonoid antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-2-phenylchromen-4-one
InChIKey
RTIXKCRFFJGDFG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as cosmetic ingredient; used within Haloxyl complex
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chrysin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Chrysin.
Regulatory Flags
eye-area
dark-circles
haloxyl-component
flavonoid
antioxidant
anti-inflammatory
periorbital
endocrine_disruptor
Known Synonyms
5-18-04-00076
BRN 0233276
5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
EINECS 207-549-7
UNII-3CN01F5ZJ5
5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHRYSIN
ChEMBL ID
CHEMBL117
Frequently Asked Questions
Is Chrysin allowed in the EU?
Chrysin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Chrysin do in cosmetics?
Chrysin functions as: Skin-brightening active; flavonoid antioxidant. It is classified as a Active Ingredient in our database. CAS number: 480-40-0.
Is Chrysin used outside cosmetics?
Chrysin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Chrysin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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