Is Dihydroquercetin safe in cosmetics?
Dihydroquercetin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dihydroquercetin
Also known as: (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one, (2R,3R)-Dihydroquercetin, 5-18-05-00451, 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, BRN 0093548 (+10 more)
INCI: DIHYDROQUERCETIN
Dihydroquercetin (CAS 480-18-2) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning. Reported NOAEL =1500 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 480-18-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
InChIKey
CXQWRCVTCMQVQX-LSDHHAIUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA cosmetic restriction; sold as dietary supplement ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydroquercetin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dihydroquercetin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1500 mg/kg bw/day | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
22.22%
DPRA Lys %
34.9%
KeratinoSens IC50
256.1 µM
hCLAT CV75
250 µg/mL
GHS: inconclusive
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Dihydroquercetin.
Regulatory Flags
antioxidant
flavonoid
taxifolin
INCI-registered-2007
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dihydroquercetin by CAS number or substance name.
Studies
1
Lowest NOAEL
1500 mg/kg bw/day
Highest NOAEL
1500 mg/kg bw/day
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
(2R,3R)-Dihydroquercetin
5-18-05-00451
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-
BRN 0093548
Catechin hydrate
EINECS 207-543-4
Flavone, 2,3-dihydro-3,3',4',5,7-pentahydroxy-
3,3',4',5,7-Pentahydroxyflavanone
Quercetin, dihydro-
UNII-9SOB9E3987
Lavitol
Flamena D
(2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
2,3-trans-dihydroquercetin
Chemical Function
Antioxidant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
(+)-TAXIFOLIN
ChEMBL ID
CHEMBL66
SOURCE
EFSA / FDA GRAS
fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Dihydroquercetin
FDA GRAS
At the notifier's request, FDA ceased to evaluate this notice
GRN
826
For use as an ingredient in conventional non-alcoholic beverages (up to 0.02 g per L), flavored fermented milk and dairy products (up to 0.02 g per kg), and chocolate products (up to 0.07 g per kg).
View full food safety profile →Frequently Asked Questions
Is Dihydroquercetin allowed in the EU?
Dihydroquercetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroquercetin do in cosmetics?
Dihydroquercetin functions as: Antioxidant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 480-18-2.
What is the NOAEL for Dihydroquercetin?
The NOAEL (No Observed Adverse Effect Level) for Dihydroquercetin is =1500 mg/kg bw/day based on a subchronic study via oral: gavage route in Rat. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Is Dihydroquercetin used outside cosmetics?
Dihydroquercetin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydroquercetin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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