Is Hydrangenol safe in cosmetics?
Hydrangenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Hydrangenol
Also known as: 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one, 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-, Isocoumarin, 3,4-dihydro-8-hydroxy-3-(p-hydroxyphenyl)-, 3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one
INCI: HYDRANGENOL
Hydrangenol (CAS 480-47-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning — bioactive dihydroisocoumarin isolated from Hydrangea spp. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 480-47-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning — bioactive dihydroisocoumarin isolated from Hydrangea spp.
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
InChIKey
DGKDFNDHPXVXHW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydrangenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hydrangenol.
Known Synonyms
8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one
1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
Isocoumarin, 3,4-dihydro-8-hydroxy-3-(p-hydroxyphenyl)-
3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HYDRANGENOL
ChEMBL ID
CHEMBL69299
Frequently Asked Questions
Is Hydrangenol allowed in the EU?
Hydrangenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrangenol do in cosmetics?
Hydrangenol functions as: Skin Conditioning — bioactive dihydroisocoumarin isolated from Hydrangea spp.. It is classified as a cosmetic ingredient in our database. CAS number: 480-47-7.
Is Hydrangenol used outside cosmetics?
Hydrangenol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydrangenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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