Is Cetrimonium Methosulfate safe in cosmetics?
Cetrimonium Methosulfate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Surfactant
Cetrimonium Methosulfate
Also known as: 1-Hexadecanaminium, N,N,N-trimethyl-, methyl sulfate, 1-Hexadecanaminium, N,N,N-trimethyl-, methyl sulfate (1:1), Ammonium, hexadecyltrimethyl, methyl sulfate, EINECS 265-352-1, UNII-277IG2X9QC (+1 more)
INCI: CETRIMONIUM METHOSULFATE
Cetrimonium Methosulfate (CAS 65060-02-8) is a cosmetic surfactant functioning as Antimicrobial, Antistatic, Hair Conditioning, Emulsifying. NOAEL 45 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 65060-02-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cetrimonium Methosulfate is classified GHS Danger (H302, H314, H315, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial, Antistatic, Hair Conditioning, Emulsifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexadecyl(trimethyl)azanium;methyl sulfate
InChIKey
OEWKLERKHURFTB-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR review of methosulfate salt specifically. CIR concluded cetrimonium chloride/bromide safe in rinse-off and up to 0.25% in leave-on.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cetrimonium Methosulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cetrimonium Methosulfate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Biocide
Emulsifier
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Cetrimonium Methosulfate.
Known Synonyms
1-Hexadecanaminium, N,N,N-trimethyl-, methyl sulfate
1-Hexadecanaminium, N,N,N-trimethyl-, methyl sulfate (1:1)
Ammonium, hexadecyltrimethyl, methyl sulfate
EINECS 265-352-1
UNII-277IG2X9QC
N,N,N-Trimethyl-1-hexadecanaminium methyl sulfate
Chemical Function
Surfactant (surface active agent)
Biocide
Anti-static agent
Emulsifier
Softener and conditioner
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cetrimonium Methosulfate allowed in the EU?
Cetrimonium Methosulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetrimonium Methosulfate do in cosmetics?
Cetrimonium Methosulfate functions as: Antimicrobial, Antistatic, Hair Conditioning, Emulsifying. It is classified as a Surfactant in our database. CAS number: 65060-02-8.
Is Cetrimonium Methosulfate used outside cosmetics?
Cetrimonium Methosulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cetrimonium Methosulfate have different safety status in cosmetics vs industrial chemicals?
Cetrimonium Methosulfate is classified GHS Danger (H302, H314, H315, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Cetrimonium Methosulfate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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