Is Disodium Cocoamphodiacetate safe in cosmetics?
Disodium Cocoamphodiacetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Surfactant
Disodium Cocoamphodiacetate
Also known as: EINECS 272-043-5, Miranol C 2M Conc., 1-(2-(Carboxymethoxy)ethyl)-1-(carboxymethyl)-4,5-dihydro-2-norcoco alkyl imidazolium compounds hydroxides inner salts disodium salts, UNII-18L9G3U51M
INCI: DISODIUM COCOAMPHODIACETATE
Disodium Cocoamphodiacetate (CAS 68650-39-5) is a cosmetic surfactant functioning as Surfactant; co-surfactant; mildness modifier. NOAEL 53 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 68650-39-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant; co-surfactant; mildness modifier
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Extremely mild amphoteric used in baby and no-tears formulations. Combined with APGs and sodium lauroamphoacetate for synergistic irritation reduction systems. pH range 5.0–8.0.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Cocoamphodiacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disodium Cocoamphodiacetate across SCCS product categories, with measured dermal absorption where available.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "68650-39-5", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_a…
baby_pediatric
{"cas_number": "CAS-82499", "ingredient_class": "cleanser_baby", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Mild derivative surfactant", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Su…
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "18", "estimated_cost_per_kg_usd_high": "32", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global", "bulk_discount_threshold_kg": "150", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Cocamidopropyl…
emulsion_hlb
{"hlb_required_as_emulsifier": "yes", "emulsifier_type": "o_w", "critical_packing_parameter": "0.25-0.38", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "cocamidopropyl_betaine", "optimal_oil_phase_pct": "5-18", "optimal_water_phase_pct": "82-95", "electrolyte_tolerance": "low", "pH_emulsion_stability_range": "4.5-9.5", "viscosity_building_contribution": "low-m…
hair_care
{"hair_function": "cleansing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "keratin…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "10.0", "adult_max_concentration_pct": "10.0", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diaper_area_s…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
sensory
{"silky": "light", "smooth, glides easily": "smooth, mild foam", "dry-touch, non-greasy": "soft, clean", "instant": "fast", "none": "medium", "low": "low", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "no", "1.40": "1.48", "transparent": "transparent", "colorless": "pale-yellow", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Foamant
Softener and conditioner
Solubility enhancer
Surfactant (surface active agent)
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Cocoamphodiacetate.
Regulatory Flags
amphoteric
amphodiacetate
baby-safe
tearless
ultra-mild
ophthalmologically-tested
synergistic-mildness
eu_children_restricted
epa_safer_alternative
Known Synonyms
EINECS 272-043-5
Miranol C 2M Conc.
1-(2-(Carboxymethoxy)ethyl)-1-(carboxymethyl)-4,5-dihydro-2-norcoco alkyl imidazolium compounds hydroxides inner salts disodium salts
UNII-18L9G3U51M
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Softener and conditioner
Cleaning agent
Foamant
Regulatory Lists
children; Europe; Personal care - hair styling and care - shampoo
Europe; Personal care - body hygiene - hand soap
children; Europe; Personal care
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Disodium Cocoamphodiacetate allowed in the EU?
Disodium Cocoamphodiacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Cocoamphodiacetate do in cosmetics?
Disodium Cocoamphodiacetate functions as: Surfactant; co-surfactant; mildness modifier. It is classified as a Surfactant in our database. CAS number: 68650-39-5.
Compliance Tools
Check Disodium Cocoamphodiacetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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