Is Bumetrizole safe in cosmetics?
Bumetrizole has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Bumetrizole
Also known as: 2-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol (2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol), 2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol, EINECS 223-445-4, Bumetrizolum, UNII-7ZF18Q354W
INCI: BUMETRIZOLE
Bumetrizole (CAS 3896-11-5) is a cosmetic cosmetic ingredient functioning as UV Absorber, Fragrance Functional. NOAEL 59 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3896-11-5 →
Auto-generated CPSR Part A draft with source citations
Function
UV Absorber, Fragrance Functional
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-tert-butyl-6-(5-chlorobenzotriazol-2-yl)-4-methylphenol
InChIKey
OCWYEMOEOGEQAN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not established for cosmetic use. No SCCS opinion. SVHC status makes cosmetic use highly problematic.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bumetrizole.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Bumetrizole across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 23-Jan-2024)
Hazard classification: Restricted (Annex XVII)
SVHC reason: vPvB (Article 57e)
Substance of Very High Concern (SVHC)
Included: 23-Jan-2024
vPvB (Article 57e)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Bumetrizole.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Bumetrizole by CAS number or substance name.
Studies
12
Lowest NOAEL
59 mg/kg bw/day
Highest NOAEL
3000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol (2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol)
2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol
EINECS 223-445-4
Bumetrizolum
UNII-7ZF18Q354W
Chemical Function
UV stabilizer
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
CEDI
Indirect additives food contact (10/2018)
detected; Europe; Other indirect contact consumer goods
pharmaceutical
Europe; plastic_additive
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BUMETRIZOLE
ChEMBL ID
CHEMBL1880325
Max Phase
2
Frequently Asked Questions
Is Bumetrizole allowed in the EU?
Bumetrizole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bumetrizole do in cosmetics?
Bumetrizole functions as: UV Absorber, Fragrance Functional. It is classified as a cosmetic ingredient in our database. CAS number: 3896-11-5.
Is Bumetrizole used outside cosmetics?
Bumetrizole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bumetrizole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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