What is the NOAEL for Bumetrizole?
Bumetrizole has 5 NOAEL studies in the database. The lowest reported value is 7ZF18Q354W UNII. Source: openFDA substances.
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
Bumetrizole
Also known as: 2-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol (2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol), 2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol, EINECS 223-445-4, Bumetrizolum, UNII-7ZF18Q354W
CAS 3896-11-5
Bumetrizole (CAS 3896-11-5) is a chemical substance; key hazard signal: vPvB (Article 57e). Key regulatory status: SVHC Candidate List, REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Bumetrizole
CAS Number
3896-11-5
DTXSID
DTXSID9036438
Molecular Formula
C17H18ClN3O
InChI Key
OCWYEMOEOGEQAN-UHFFFAOYSA-N
Monoisotopic Mass
315.11384
Synonyms
2-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol (2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresol)2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-p-cresolEINECS 223-445-4BumetrizolumUNII-7ZF18Q354W
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| Bumetrizole (UV-326) | vPvB (Article 57e) | 23-Jan-2024 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
45 records
UV stabilizerFragranceAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7ZF18Q354W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7ZF18Q354W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7ZF18Q354W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7ZF18Q354W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bumetrizole | 223-445-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BUMETRIZOLE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Bumetrizole?
Bumetrizole appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, CEDI, and 5 more. Source: EPA CPDat.
Is Bumetrizole a Substance of Very High Concern (SVHC)?
Yes, Bumetrizole is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: vPvB (Article 57e). Source: ECHA SVHC Candidate List.
Is Bumetrizole used in cosmetics?
Yes, Bumetrizole is also indexed as a cosmetic ingredient under the name Bumetrizole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bumetrizole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Bumetrizole used outside industrial chemicals?
Bumetrizole also appears in cosmetics, pharmaceutical databases.