Also known as: 2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane, 2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(2-hydroxypropoxy)phenyl)propane (+14 more)
Bisphenol A Bis-(2-Hydroxypropyl) Ether (CAS 116-37-0) is a cosmetic cosmetic ingredient functioning as No specific technical function. Reported NOAEL =75 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bisphenol A Bis-(2-Hydroxypropyl) Ether.
Calculate MoS for your specific formulation with the
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Toxicological Studies
3 study endpoints found for Bisphenol A Bis-(2-Hydroxypropyl) Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=75 mg/kg bw/day
oral
Rabbit
developmental
ToxValDB_ECHA_IUCLID
NOAEL
=100 mg/kg bw/day
oral
Rat
reproduction developmental
ToxValDB_ECHA_IUCLID
NOAEL
=125 mg/kg bw/day
oral
Rat
short-term
ToxValDB_ECHA_IUCLID
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Bisphenol A Bis-(2-Hydroxypropyl) Ether.
Public NOAEL study rows linked to Bisphenol A Bis-(2-Hydroxypropyl) Ether by CAS number or substance name.
Studies
3
Lowest NOAEL
75 mg/kg bw/day
Highest NOAEL
125 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane2,2-Bis(4-(2-hydroxypropoxy)phenyl)propaneBisphenol A bis(beta-hydroxypropyl) etherBisphenol A-propylene oxide adduct (1:2)Dow Resin 565EINECS 204-137-9Hydroxypropylated diphenylolpropane1,1'-(Isopropylidenebis(p-phenyleneoxy))di-2-propanolIsopropylidenediphenoxypropanol1,1'-((1-Methylethylidene)bis(4,1-phenyleneoxy))bis-2-propanolNSC 4084942-Propanol, 1,1'-isopropylidenebis(p-phenyleneoxy)di-UNII-S5K2510L3D2,2-Bis[4-(2-hydroxy-2-methylethoxy)phenyl]propaneBisphenol A propoxylateBis-HPPP
Chemical Function
No specific technical function
Regulatory Lists
CEDIIndirect additives food contact (10/2018)
Australian Status
AICIS status:listed
Frequently Asked Questions
Is Bisphenol A Bis-(2-Hydroxypropyl) Ether safe in cosmetics?
Bisphenol A Bis-(2-Hydroxypropyl) Ether has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Is Bisphenol A Bis-(2-Hydroxypropyl) Ether allowed in the EU?
Bisphenol A Bis-(2-Hydroxypropyl) Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bisphenol A Bis-(2-Hydroxypropyl) Ether do in cosmetics?
Bisphenol A Bis-(2-Hydroxypropyl) Ether functions as: No specific technical function. It is classified as a cosmetic ingredient in our database. CAS number: 116-37-0.
What is the NOAEL for Bisphenol A Bis-(2-Hydroxypropyl) Ether?
The NOAEL (No Observed Adverse Effect Level) for Bisphenol A Bis-(2-Hydroxypropyl) Ether is =75 mg/kg bw/day based on a developmental study via oral route in Rabbit. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Bisphenol A Bis-(2-Hydroxypropyl) Ether used outside cosmetics?
Bisphenol A Bis-(2-Hydroxypropyl) Ether also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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