What is the NOAEL for Bisphenol A bis(2-hydroxypropyl) ether?
Bisphenol A bis(2-hydroxypropyl) ether has 11 NOAEL studies in the database. The lowest reported value is 17.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Bisphenol A bis(2-hydroxypropyl) ether
Also known as: 2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane, 2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(2-hydroxypropoxy)phenyl)propane (+14 more)
CAS 116-37-0
Bisphenol A bis(2-hydroxypropyl) ether (CAS 116-37-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Bisphenol A Bis-(2-Hydroxypropyl) Ether →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Bisphenol A bis(2-hydroxypropyl) ether
CAS Number
116-37-0
DTXSID
DTXSID8051592
Molecular Formula
C21H28O4
InChI Key
MIUUNYUUEFHIHM-UHFFFAOYSA-N
Monoisotopic Mass
344.198759
Synonyms
2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane2,2-Bis(4-(2-hydroxypropoxy)phenyl)propaneBisphenol A bis(beta-hydroxypropyl) etherBisphenol A-propylene oxide adduct (1:2)Dow Resin 565EINECS 204-137-9Hydroxypropylated diphenylolpropane1,1'-(Isopropylidenebis(p-phenyleneoxy))di-2-propanolIsopropylidenediphenoxypropanol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| S5K2510L3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5K2510L3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5K2510L3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5K2510L3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =75 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=180 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include Bisphenol A bis(2-hydroxypropyl) ether?
Bisphenol A bis(2-hydroxypropyl) ether appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Bisphenol A bis(2-hydroxypropyl) ether used in cosmetics?
Yes, Bisphenol A bis(2-hydroxypropyl) ether is also indexed as a cosmetic ingredient under the name Bisphenol A Bis-(2-Hydroxypropyl) Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bisphenol A bis(2-hydroxypropyl) ether come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Bisphenol A bis(2-hydroxypropyl) ether used outside industrial chemicals?
Bisphenol A bis(2-hydroxypropyl) ether also appears in cosmetics databases.