Is 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE safe in cosmetics?
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE
Also known as: Dehydro-beta-cyclocitral, EINECS 204-133-7, FEMA No. 3389, 2,6,6-Trimethyl-1,3-cyclohexadienal, (2,6,6-Trimethylcyclohexa-1,3-dienyl)methanal (+4 more)
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE (CAS 116-26-7) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =125 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 116-26-7 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde
InChIKey
SGAWOGXMMPSZPB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =125 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >300 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | <2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | =125 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =125 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =125 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOEL | =50 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| LEL | =120 mg/kg-day | Rat | oral | subchronic | EFSA |
| LEL | =120 mg/kg-day | Dog | oral | subchronic | EFSA |
| NOEL | =10 mg/kg-day | Rat | oral | subchronic | EFSA |
| LEL | =120 mg/kg-day | Rat | oral | subchronic | EFSA |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
91.8%
DPRA Lys %
0%
KeratinoSens IC50
337.267 µM
LLNA EC3
7.5%
NESIL
300 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [277] RIFM (1996): RIFM report number 29893, July 3, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 99 | 1 | 59 | - | - |
| HRIPT | 105 | 0 | 29 | 29 | non-sensitizer |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | 300 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1A (Strong sensitizer) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (7)
JECFA Number
977
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,1,3-TRIMETHYL-2-FORMYLCYCLOHEXA-2,4-DIENE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
SAFRANAL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DEHYDRO-beta-CYCLOCITRAL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE by CAS number or substance name.
Studies
4
Lowest NOAEL
125 mg/kg bw/day
Highest NOAEL
125 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Dehydro-beta-cyclocitral
EINECS 204-133-7
FEMA No. 3389
2,6,6-Trimethyl-1,3-cyclohexadienal
(2,6,6-Trimethylcyclohexa-1,3-dienyl)methanal
UNII-4393FR07EA
1,1,3-Trimethyl-2-formylcyclohexa-2,4-diene
2,6,6-Trimethylcyclohexa-1,3-dienyl methanal
2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183495
Frequently Asked Questions
Is 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE allowed in the EU?
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE do in cosmetics?
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 116-26-7.
What is the NOAEL for 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE?
The NOAEL (No Observed Adverse Effect Level) for 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE is =125 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE used outside cosmetics?
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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