NOAEL Studies Cosmetic Ingredient

Bisphenol A Bis-(2-Hydroxypropyl) Ether NOAEL Studies

CAS: 116-37-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =75 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb02; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/9/3?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15823454:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_92407ad698e362e7dff73712e2ae68f1
ToxValDB_ECHA_IUCLID NOAEL >=250 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/9/3?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15824087:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_de84c568fc639a25a7c414f4129b0d38
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/9/3?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15824088:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bc58cb33ff260e34070db2807b999278
ToxValDB_ECHA_IUCLID NOAEL =125 mg/kg bw/day Rat oral short-term; 29 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c19b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/6/2?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15850456:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9de47bbb5d6c5dd3cbe1587b55dbd56c
ToxValDB_ECHA_IUCLID NOAEL >=180 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c19b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/6/2?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15850457:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c33d7db27339488f789501bc2c78f816
ToxValDB_ECHA_IUCLID NOAEL >=500 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5a5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1336/7/9/2?documentUUID=0ed1514d-4845-40b8-a8f5-1667f7758e7d; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15861452:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c0e36c71bc7c95b619166abdd2462155
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632889:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6dedceb5b8f024a6fdd1d1805f6cbe0b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S5K2510L3D UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S5K2510L3D"}
openFDA substances FDA UNII substance identifier S5K2510L3D UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S5K2510L3D"}
openFDA substances FDA UNII substance identifier S5K2510L3D UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S5K2510L3D"}
openFDA substances FDA UNII substance identifier S5K2510L3D UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S5K2510L3D"}