Is 2-Methylbutyric Acid safe in cosmetics?
2-Methylbutyric Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Methylbutyric Acid
Also known as: 4-02-00-00889, BRN 1098537, EINECS 204-145-2, EINECS 209-982-7, FEMA No. 2695 (+14 more)
INCI: 2-METHYLBUTYRIC ACID
2-Methylbutyric Acid (CAS 116-53-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 116-53-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Methylbutyric Acid is classified GHS Danger (H302, H312, H314, H318, H290) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methylbutanoic acid
InChIKey
WLAMNBDJUVNPJU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methylbutyric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
255
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYLBUTYRIC ACID | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methylbutyric Acid.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-00889
BRN 1098537
EINECS 204-145-2
EINECS 209-982-7
FEMA No. 2695
Valeric acid, active
UNII-PX7ZNN5GXK
(+/-)-2-Methylbutyrate
(+/-)-2-Methylbutyric acid
2-Ethylpropionate
2-Ethylpropionic acid
2-Methyl Butyrate
2-Methyl Butyric acid
2-Methylbutanoate
2-methybutyric acid
D-2-Methyl Butyrate
D-2-Methyl Butyric acid
DL-2-Methy Butyrate
DL-2-Methy Butyric acid
Chemical Function
Fragrance
Flavouring and nutrient
Dispersing agent
Regulatory Lists
Canada; pharmaceutical
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1160012
Frequently Asked Questions
Is 2-Methylbutyric Acid allowed in the EU?
2-Methylbutyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methylbutyric Acid do in cosmetics?
2-Methylbutyric Acid functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 116-53-0.
Is 2-Methylbutyric Acid used outside cosmetics?
2-Methylbutyric Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Methylbutyric Acid have different safety status in cosmetics vs industrial chemicals?
2-Methylbutyric Acid is classified GHS Danger (H302, H312, H314, H318, H290) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Methylbutyric Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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