Is Acetyl Hexapeptide-8 safe in cosmetics?
Acetyl Hexapeptide-8 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Acetyl Hexapeptide-8
Also known as: N-[(3S)-3-Acetamido-5-carboxy-1-penten-2-yl]-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide, L-Argininamide, N-[(2S)-2-(acetylamino)-4-carboxy-1-methylenebutyl]-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-, l-Argininamide, N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyll-l-arginyl-, Acetyl-glu-glu-met-gln-arg-arg-amide, UNII-L4EL31FWIL (+1 more)
INCI: ACETYL HEXAPEPTIDE-8
Acetyl Hexapeptide-8 (CAS 616204-22-9) is a cosmetic active ingredient functioning as Skin-conditioning agent; neuromodulating peptide. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 616204-22-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent; neuromodulating peptide
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
AJLNZWYOJAWBCR-OOPVGHQCSA-N
SMILES
CC(=O)NC(CCC(=O)O)C(=C)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as cosmetic ingredient; no concentration cap, but ocular surface concerns flagged in clinical literature
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Hexapeptide-8.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
d palmitoyl tetrapeptide-7 as used in cosmetics.2 The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration, as described in that safety assessment. (This report is available on the Cosmetic Ingredient Review (CIR) website: https://cir-reports.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
amino_acid
{"cas_number": "616204-22-9", "ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "889", "amino_acid_composition_key": "acetyl_EEMQRR", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "derm…
anti_pollution
{"cas_number": "616204-22-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
baby_pediatric
{"cas_number": "616204-22-9", "ingredient_class": "other", "pediatric_safety_rating": "avoid", "minimum_age_months": "24", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Botox-like - adult", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein fragme…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,combination,normal,mature", "acne_safe": "yes", "source": "Argireline"}
concentration
{"min_concentration_pct": "0.05", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.3", "product_type": "Eye Cream", "function_at_concentration": "Wrinkle reduction", "source": "Supplier TDS"}
hair_care
{"hair_function": "conditioning", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "kera…
peptide
{"cas_number": "616204-22-9", "trade_name": "Argireline / SNAP-6", "peptide_sequence_amino_acids": "Ac-Glu-Glu-Met-Gln-Arg-Arg", "peptide_length_residues": "6", "molecular_weight_daltons": "888.9", "peptide_class": "neurotransmitter_inhibitor", "mechanism_of_action": "Inhibits SNARE complex formation, reduces acetylcholine release at neuromuscular junction", "target_protein_or_receptor": "SNAP-25/…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Hexapeptide-8.
Regulatory Flags
peptide
neuromodulating
ocular-surface-concern
blink-disruption
argireline
eye-area-caution
Known Synonyms
N-[(3S)-3-Acetamido-5-carboxy-1-penten-2-yl]-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
L-Argininamide, N-[(2S)-2-(acetylamino)-4-carboxy-1-methylenebutyl]-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-
l-Argininamide, N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyll-l-arginyl-
Acetyl-glu-glu-met-gln-arg-arg-amide
UNII-L4EL31FWIL
Hexapeptide 3
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Frequently Asked Questions
Is Acetyl Hexapeptide-8 allowed in the EU?
Acetyl Hexapeptide-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Hexapeptide-8 do in cosmetics?
Acetyl Hexapeptide-8 functions as: Skin-conditioning agent; neuromodulating peptide. It is classified as a Active Ingredient in our database. CAS number: 616204-22-9.
Is Acetyl Hexapeptide-8 used outside cosmetics?
Acetyl Hexapeptide-8 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acetyl Hexapeptide-8 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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