Is Hexapeptide-8 safe in cosmetics?
Hexapeptide-8 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexapeptide-8
INCI: HEXAPEPTIDE-8
Hexapeptide-8 (CAS 616204-22-9 (Acetyl Hexapeptide-8 Amide)) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 616204-22-9 (Acetyl Hexapeptide-8 Amide) →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted, not restricted under 21 CFR. CIR Expert Panel concluded safe at ≤0.005% in leave-on products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-8.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-8.
Frequently Asked Questions
Is Hexapeptide-8 allowed in the EU?
Hexapeptide-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-8 do in cosmetics?
Hexapeptide-8 functions as: Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle. It is classified as a cosmetic ingredient in our database. CAS number: 616204-22-9 (Acetyl Hexapeptide-8 Amide).
Compliance Tools
Check Hexapeptide-8 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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