Is ACETYL HEXAPEPTIDE-24 AMIDE safe in cosmetics?
ACETYL HEXAPEPTIDE-24 AMIDE has a safety rating of "GOOD" in our database. EU status: permitted. This ingredient has been reviewed by cir.
ACETYL HEXAPEPTIDE-24 AMIDE
Also known as: N-[(3S)-3-Acetamido-5-carboxy-1-penten-2-yl]-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide, L-Argininamide, N-[(2S)-2-(acetylamino)-4-carboxy-1-methylenebutyl]-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-, l-Argininamide, N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyll-l-arginyl-, Acetyl-glu-glu-met-gln-arg-arg-amide, UNII-L4EL31FWIL (+1 more)
ACETYL HEXAPEPTIDE-24 AMIDE (CAS 616204-22-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 616204-22-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
AJLNZWYOJAWBCR-OOPVGHQCSA-N
SMILES
CC(=O)NC(CCC(=O)O)C(=C)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
d palmitoyl tetrapeptide-7 as used in cosmetics.2 The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration, as described in that safety assessment. (This report is available on the Cosmetic Ingredient Review (CIR) website: https://cir-reports.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for ACETYL HEXAPEPTIDE-24 AMIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
N-[(3S)-3-Acetamido-5-carboxy-1-penten-2-yl]-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
L-Argininamide, N-[(2S)-2-(acetylamino)-4-carboxy-1-methylenebutyl]-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-
l-Argininamide, N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyll-l-arginyl-
Acetyl-glu-glu-met-gln-arg-arg-amide
UNII-L4EL31FWIL
Hexapeptide 3
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Frequently Asked Questions
Is ACETYL HEXAPEPTIDE-24 AMIDE allowed in the EU?
ACETYL HEXAPEPTIDE-24 AMIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ACETYL HEXAPEPTIDE-24 AMIDE do in cosmetics?
ACETYL HEXAPEPTIDE-24 AMIDE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 616204-22-9.
Is ACETYL HEXAPEPTIDE-24 AMIDE used outside cosmetics?
ACETYL HEXAPEPTIDE-24 AMIDE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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