Is 3-Methoxybutanol safe in cosmetics?
3-Methoxybutanol has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
3-Methoxybutanol
Also known as: 1-Butanol, 3-methoxy-, EINECS 219-741-8, 3-Methoxy-1-butanol, NSC 65580, UNII-SJ995B41AO
INCI: 3-METHOXYBUTANOL
3-Methoxybutanol (CAS 2517-43-3) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2517-43-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
3-Methoxybutanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
3-methoxybutan-1-ol
InChIKey
JSGVZVOGOQILFM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically restricted by FDA for cosmetics, but classified as a reproductive toxicant internationally
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Methoxybutanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 3-Methoxybutanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | injection | Guinea Pig | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 3-Methoxybutanol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for 3-Methoxybutanol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 3-Methoxybutanol by CAS number or substance name.
Studies
1
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1-Butanol, 3-methoxy-
EINECS 219-741-8
3-Methoxy-1-butanol
NSC 65580
UNII-SJ995B41AO
Chemical Function
Solvent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186019
Frequently Asked Questions
Is 3-Methoxybutanol allowed in the EU?
3-Methoxybutanol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Methoxybutanol do in cosmetics?
3-Methoxybutanol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 2517-43-3.
What is the NOAEL for 3-Methoxybutanol?
The NOAEL (No Observed Adverse Effect Level) for 3-Methoxybutanol is =100 mg/kg bw/day based on a short-term study via injection route in Guinea Pig. Source: ToxValDB_ECHA_IUCLID.
Is 3-Methoxybutanol used outside cosmetics?
3-Methoxybutanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 3-Methoxybutanol have different safety status in cosmetics vs industrial chemicals?
3-Methoxybutanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226).
Compliance Tools
Check 3-Methoxybutanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
C10-13 Isoparaffin
Excellent
Same category
Solvent
C9-14 Isoparaffin
Excellent
Same category
Solvent
PPG-10 Butanediol
Excellent
Same category
Solvent
Phosphate Buffered Saline
Excellent
Same category
Solvent, buffering agent
Water
Excellent
Same category
Solvent, vehicle/carrier
1,10-Decanediol
Good
Same category
Solvent
1,2,4-Benzenetriacetate
Poor
Similar safety
Hair dye precursor (triacetyl ester o...
1,2,4-Trihydroxybenzene
Poor
Similar safety
Hair colorant (auto-oxidative dye)
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
3-METHYL-4-(2,4,6-TRIMETHYL-3-CYCLOHEXENYL)-3-BUTEN-2-ONE
Good
Browse nearby
Perfuming
3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL
Good
Browse nearby
Perfuming
3-METHYL-5-PROPYL-2-CYCLOHEXENONE
Good
Browse nearby
Perfuming
Is 3-Methoxybutanol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 3-Methoxybutanol in your formulation.