Good Cosmetic Ingredient NOAEL Data Sensitization Data

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL

Also known as: 4-Penten-2-ol, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-, EINECS 267-140-4, 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol (& isomer), Ebanol

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL (CAS 67801-20-1) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 67801-20-1 →

Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C14H24O
MW
208.34 g/mol
EC Number
267-140-4
PubChem CID
6437266
IUPAC Name
(Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol
InChIKey
RNLHVODSMDJCBR-VURMDHGXSA-N

Regulatory Status

EU EU Status permitted
US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =1000 mg/kg bw/day oral Rat short-term ToxValDB_ECHA_IUCLID

Sensitization Profile

Contact sensitization data for 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Additional Ingredient Properties

1 property record from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (1)
JECFA Evaluation
3-METHYL-5-(2,2,3-TRIMETHYLCYCLOPENT- 3-EN-1-YL)PENT-4-EN-2-OL | 2016 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 1000-JECFA 82/105 | FAS 73 JECFA 82/383
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List

Expert Verdict

Expert safety assessment and concern-level summary for 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL.

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL by CAS number or substance name.

Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

4-Penten-2-ol, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)- EINECS 267-140-4 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol (& isomer) Ebanol

Chemical Function

Fragrance

Regulatory Lists

IFRA Transparency

Australian Status

AICIS status: listed

Frequently Asked Questions

Is 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL safe in cosmetics?

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL allowed in the EU?

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL do in cosmetics?

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 67801-20-1.

What is the NOAEL for 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL?

The NOAEL (No Observed Adverse Effect Level) for 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL used outside cosmetics?

3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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