Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

1-Nitropropane

Also known as: EINECS 203-544-9, UNII-39W305OW99, 3-nitropropane, nitropropane

CAS 108-03-2

1-Nitropropane (CAS 108-03-2) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H332; H312; H302. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for 1-Nitropropane →

Cross-Vertical Regulatory Divergence

1-Nitropropane is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332, H312, H302).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

1-Nitropropane

CAS Number

108-03-2

DTXSID

DTXSID1020980

Molecular Formula

C3H7NO2

InChI Key

JSZOAYXJRCEYSX-UHFFFAOYSA-N

Monoisotopic Mass

89.047678

Synonyms

EINECS 203-544-9UNII-39W305OW993-nitropropanenitropropane

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; Acute Tox. 4 ; Acute Tox. 4 ; Acute Tox. 4 *	H226; H332; H312; H302	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and respiratory tract.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	25 ppm (90 mg/m³)	25	90	N
NIOSH	TWA	25 ppm (90 mg/m³)	25	90	N
ACGIH	TWA	25 ppm [1992]	25	-	N
CAL/OSHA	TWA	25 ppm (90 mg/m³)	25	90	N
NIOSH	IDLH	1000 ppm	1000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Solvent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
=3.6	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=7.1	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
39W305OW99	UNII	FDA UNII substance identifier	-	-	openFDA substances
39W305OW99	UNII	FDA UNII substance identifier	-	-	openFDA substances
39W305OW99	UNII	FDA UNII substance identifier	-	-	openFDA substances
39W305OW99	UNII	FDA UNII substance identifier	-	-	openFDA substances
11.02	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
11.2891	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=80166.8	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=100	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=349.819	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=364.394	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=174.909	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=91.0986	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=182.197	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=364.394	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=30	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1-nitropropane	203-544-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1449933

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Nitropropane?

1-Nitropropane (CAS 108-03-2) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H226; H332; H312; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Nitropropane?

1-Nitropropane has 17 NOAEL studies in the database. The lowest reported value is 3.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What are the occupational exposure limits for 1-Nitropropane?

Occupational exposure limits for 1-Nitropropane are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1-Nitropropane used in cosmetics?

Yes, 1-Nitropropane is also indexed as a cosmetic ingredient under the name 1-Nitropropane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Nitropropane come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Nitropropane have different safety status in cosmetics vs industrial chemicals?

1-Nitropropane is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332, H312, H302).

Is 1-Nitropropane used outside industrial chemicals?

1-Nitropropane also appears in cosmetics, pharmaceutical databases.