Is ZINC DIBUTYLDITHIOCARBAMATE safe in cosmetics?
ZINC DIBUTYLDITHIOCARBAMATE has a safety rating of "MODERATE" in our database. EU status: restricted. 5 toxicological study endpoint(s) are available in our database.
ZINC DIBUTYLDITHIOCARBAMATE
Also known as: Zinc, bis(dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)-, Accel BZ, Aceto ZDBD, Bis(dibutyldithiocarbamato)zinc, Bis(N,N-dibutyldithiocarbamato)zinc (+15 more)
ZINC DIBUTYLDITHIOCARBAMATE (CAS 136-23-2) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Antioxidant. NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max III/24. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 136-23-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
zinc bis(N,N-dibutylcarbamodithioate)
InChIKey
BOXSVZNGTQTENJ-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/24
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
5 study endpoints found for ZINC DIBUTYLDITHIOCARBAMATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =41 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =47 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =75 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for ZINC DIBUTYLDITHIOCARBAMATE across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for ZINC DIBUTYLDITHIOCARBAMATE based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
rubber
EU Allergen Listed
no
Patch Test Positive Rate
1.0%
Cross-reactivity Group
thiuram-carbamate-group
Reaction Type
contact-dermatitis
Source: ESSCA 2019/20; IVDK; NACDG
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantEnvironmental Hazard
Hazard Class and Category
STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "rubber", "cross_reactivity_group": "thiuram-carbamate-group", "patch_test_frequency_pct": "1.0", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "ESSCA 2019/20; IVDK; NACDG"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Catalyst
Chemical reaction regulator
Processing aids not otherwise specified
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for ZINC DIBUTYLDITHIOCARBAMATE.
Regulatory Flags
cosing-sourced
eu-restricted
preservative
antioxidant
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ZINC DIBUTYLDITHIOCARBAMATE by CAS number or substance name.
Studies
5
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Zinc, bis(dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)-
Accel BZ
Aceto ZDBD
Bis(dibutyldithiocarbamato)zinc
Bis(N,N-dibutyldithiocarbamato)zinc
Butazate
Butazate 50-D
Butyl zimate
Butyl ziram
Carbamic acid, dibutyldithio-, zinc complex
Carbamodithioic acid, dibutyl-, zinc salt
(Dibutyldithiocarbamato)zinc(II)
Dibutyldithiocarbamic acid zinc salt
EINECS 205-232-8
Nocceler BZ
NSC 36548
Soxinol BZ
Vulcacure ZB
Vulkacit LDB
Vulkacit ldb/C
Chemical Function
Biocide
Antioxidant
Processing aids not otherwise specified
Catalyst
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2373108
Frequently Asked Questions
Is ZINC DIBUTYLDITHIOCARBAMATE allowed in the EU?
ZINC DIBUTYLDITHIOCARBAMATE EU regulatory status: restricted. Maximum allowed concentration: III/24. This is based on EU Regulation 1223/2009 and its amendments.
What does ZINC DIBUTYLDITHIOCARBAMATE do in cosmetics?
ZINC DIBUTYLDITHIOCARBAMATE functions as: Antimicrobial, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 136-23-2.
What is the NOAEL for ZINC DIBUTYLDITHIOCARBAMATE?
The NOAEL (No Observed Adverse Effect Level) for ZINC DIBUTYLDITHIOCARBAMATE is =10 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is ZINC DIBUTYLDITHIOCARBAMATE used outside cosmetics?
ZINC DIBUTYLDITHIOCARBAMATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ZINC DIBUTYLDITHIOCARBAMATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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