NOAEL Studies Cosmetic Ingredient

ZINC DIBUTYLDITHIOCARBAMATE NOAEL Studies

CAS: 136-23-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b3428; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/8?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15820337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fb3414f4dfcc6058280d7f7ce605bf39
ToxValDB_ECHA_IUCLID NOAEL =3330 ppm Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f937; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/9/3?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821088:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f2a2c3bb0376dbfa9f989758797ff59
ToxValDB_ECHA_IUCLID NOAEL =75 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc32f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/9/3?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824318:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f2899a332cff24ef52de3badc96ae217
ToxValDB_ECHA_IUCLID NOAEL =41 mg/kg bw/day Rat oral chronic; 17 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221f0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/6/2?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15847511:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bb129e1471a45407ad01286f13a10dcd
ToxValDB_ECHA_IUCLID NOAEL =47 mg/kg bw/day Rat oral chronic; 17 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221f0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/6/2?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15848446:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_119ca9981ed018d00eadae781009276e
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead4be4b0a7c65d1c385e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11171/7/6/2?documentUUID=399a2625-72a2-4020-ba51-f340c43d28d0; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECHA IUCLID:15850714:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_47d5a01d04b0fdf995bfd19dcf9b244d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635764:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acb26a04e09e9769a859a553364b51f4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HNM5J934VP UNII - - - chemical {"approval_status":null,"molecular_formula":"2C9H18NS2.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HNM5J934VP"}
openFDA substances FDA UNII substance identifier HNM5J934VP UNII - - - chemical {"approval_status":null,"molecular_formula":"2C9H18NS2.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HNM5J934VP"}
openFDA substances FDA UNII substance identifier HNM5J934VP UNII - - - chemical {"approval_status":null,"molecular_formula":"2C9H18NS2.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HNM5J934VP"}
openFDA substances FDA UNII substance identifier HNM5J934VP UNII - - - chemical {"approval_status":null,"molecular_formula":"2C9H18NS2.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HNM5J934VP"}