Is Vinyl Cyclohexene Dioxide safe in cosmetics?
Vinyl Cyclohexene Dioxide has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Vinyl Cyclohexene Dioxide
Also known as: 1-Ethyleneoxy-3,4-epoxycyclohexane, 4-Vinylcyclohexene Dioxide, 1-Vinyl-3-cyclohexene dioxide, 7-Oxabicyclo[4.1.0]heptane, 3-(2-oxiranyl)-, 3-(2-Oxiranyl)-7-oxabicyclo[4.1.0]heptane (+13 more)
INCI: 4-VINYL-1-CYCLOHEXENE DIEPOXIDE
Vinyl Cyclohexene Dioxide (CAS 106-87-6) is a cosmetic cosmetic ingredient functioning as Industrial epoxy resin diluent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 106-87-6 →
Auto-generated CPSR Part A draft with source citations
Function
Industrial epoxy resin diluent
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not approved for cosmetics. California Prop 65 listed carcinogen and reproductive toxicant. NTP reasonably anticipated to be a human carcinogen.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vinyl Cyclohexene Dioxide.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. Exposure at high levels could cause death. The effects may be delayed. Medical observation is indicated. See Notes.
Long-term Exposure Effects
The substance may have effects on the kidneys, ovary and testes. This may result in tissue lesions. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
Sup 7, 60
Evaluation Year
1994
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardAcute Toxicity
Hazard Class and Category
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4
Hazard Statements
- H350 May cause cancer
- H341 Suspected of causing genetic defects
- H360F
- H331 Toxic if inhaled
- H302 Harmful if swallowed
Specific Concentration Limits / M-factors
inhalation: ATE = 0.5 mg/L dusts or mists; oral: ATE = 1847.0 mg/kg bw
Inserted via ATP: ATP17
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1469
(EU) 2019/831
CMR: Carcinogenic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1469
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Function Categories & List Membership
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Vinyl Cyclohexene Dioxide.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
1-Ethyleneoxy-3,4-epoxycyclohexane
4-Vinylcyclohexene Dioxide
1-Vinyl-3-cyclohexene dioxide
7-Oxabicyclo[4.1.0]heptane, 3-(2-oxiranyl)-
3-(2-Oxiranyl)-7-oxabicyclo[4.1.0]heptane
7-Oxabicyclo[4.1.0]heptane, 3-(epoxyethyl)-
7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-
5-19-01-00295
BRN 0106071
Chissonox 206 monomer
Cyclohexane, 1,2-epoxy-4-(epoxyethyl)-
EINECS 203-437-7
1,2-Epoxy-4-(epoxyethyl)cyclohexane
NCI-C60135
NCI-C60139
NSC 54752
UCET textile finish 11-74 (Obs.)
4-Vinlycyclohexene dioxide
Regulatory Lists
banned; Europe; Personal care
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1734307
Frequently Asked Questions
Is Vinyl Cyclohexene Dioxide allowed in the EU?
Vinyl Cyclohexene Dioxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Vinyl Cyclohexene Dioxide do in cosmetics?
Vinyl Cyclohexene Dioxide functions as: Industrial epoxy resin diluent. It is classified as a cosmetic ingredient in our database. CAS number: 106-87-6.
Is Vinyl Cyclohexene Dioxide used outside cosmetics?
Vinyl Cyclohexene Dioxide also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Vinyl Cyclohexene Dioxide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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