Also known as: 4-Vinyl-1-cyclohexene diepoxide, 1-Ethyleneoxy-3,4-epoxycyclohexane, 4-Vinylcyclohexene Dioxide, 1-Vinyl-3-cyclohexene dioxide, Vinyl cyclohexene dioxide (+15 more)
CAS 106-87-6
4-Vinyl-1-cyclohexene dioxide (CAS 106-87-6) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H341; H360F; H331; H302. Key regulatory status: California Proposition 65, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, CA Prop 65, ILO ICSC, OSHA.
View cosmetic safety profile for Vinyl Cyclohexene Dioxide →
4-Vinyl-1-cyclohexene dioxide is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H341, H360F, H331, H302).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1994 | Sup 7, 60 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
| - | female, male | No | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4 | H350; H341; H360F; H331; H302 | GHS08; GHS06 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. Exposure at high levels could cause death. The effects may be delayed. Medical observation is indicated. See Notes. |
| Long-term Effects | The substance may have effects on the kidneys, ovary and testes. This may result in tissue lesions. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 10 ppm (60 mg/m³) | 10 | 60 | Y |
| ACGIH | TWA | 0.1 ppm [1994] | 0.1 | - | Y |
| CAL/OSHA | TWA | 0.1 ppm (0.57 mg/m³) | 0.1 | 0.57 | Y |
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 136 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 596C064IG4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 596C064IG4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 596C064IG4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 596C064IG4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 4.5839 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =2130 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 30 | mg/animal/day | POLY-3 lowest dose | Dermal | Mouse | NTP_ICE_cancer |
| 100 | mg/mL | Top dose | Dermal | Rat | NTP_ICE_cancer |
Showing 23 of 23 studies
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
4-Vinyl-1-cyclohexene dioxide (CAS 106-87-6) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4 with signal word Danger. Hazard statements: H350; H341; H360F; H331; H302. Source: EU CLP Annex VI (ECHA).
4-Vinyl-1-cyclohexene dioxide has 23 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
4-Vinyl-1-cyclohexene dioxide appears on 3 regulatory/inventory lists including banned; Europe; Personal care, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
4-Vinyl-1-cyclohexene dioxide is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1994). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 4-Vinyl-1-cyclohexene dioxide is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for 4-Vinyl-1-cyclohexene dioxide are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 4-Vinyl-1-cyclohexene dioxide is also indexed as a cosmetic ingredient under the name Vinyl Cyclohexene Dioxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
4-Vinyl-1-cyclohexene dioxide is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H341, H360F, H331, H302).
4-Vinyl-1-cyclohexene dioxide also appears in cosmetics, pharmaceutical databases.