Is Trisodium Ethylenediamine Disuccinate safe in cosmetics?
Trisodium Ethylenediamine Disuccinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Trisodium Ethylenediamine Disuccinate
Also known as: l-aspartic acid, N,N'-1,2-ethanediylbis-, trisodium salt, UNII-YA22H34H9Q, Natriquest E30, Octaquest E 30, ENVIOMET C 140 (+1 more)
INCI: TRISODIUM ETHYLENEDIAMINE DISUCCINATE
Trisodium Ethylenediamine Disuccinate (CAS 178949-82-1) is a cosmetic cosmetic ingredient functioning as Chelating agent; metal ion sequestrant; biodegradable EDTA alternative. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 178949-82-1 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent; metal ion sequestrant; biodegradable EDTA alternative
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
trisodium;(2S)-2-[2-[[(1S)-1-carboxy-2-carboxylatoethyl]amino]ethylamino]butanedioate
InChIKey
QEHXDDFROMGLSP-VDBFCSKJSA-K
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not classified as a sunscreen active. No FDA restrictions on cosmetic use. CIR Expert Panel (March 2023) concluded safe in present practices. 199 VCRP-reported formulations. Max use: 0.64% rinse-off, 0.56% leave-on. Single positive in vitro genotoxicity result outweighed by negative Ames and negative in vivo micronucleus assay. Reproductive effects at 1,000 mg/kg/day oral deemed irrelevant at cosmetic exposure levels.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trisodium Ethylenediamine Disuccinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Trisodium Ethylenediamine Disuccinate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
8 property records from structured ingredient metadata.
anti_pollution
{"cas_number": "178949-82-1", "ingredient_class": "heavy_metal_chelator", "primary_mechanism": "chelation", "pollution_types_targeted": "heavy_metals", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF…
baby_pediatric
{"cas_number": "164462-16-2", "ingredient_class": "other", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Biodegradable chelator", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Chelator/buffer func…
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "28", "estimated_cost_per_kg_usd_high": "50", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Europe", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "EDTA, Tetrasod…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "60-90", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
sensory
{"silky": "liquid", "smooth, glides easily": "smooth, chelating", "dry-touch, non-greasy": "stabilized, protected", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.18", "transparent": "transparent", "colorless": "colorless", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
supply_chain
{"primary_producing_countries": "Germany, China, USA", "secondary_producing_countries": "Netherlands, Japan", "raw_material_origin": "synthetic", "agricultural_crop_or_wild_harvested": "petrochemical", "cultivation_climate_required": "industrial", "harvest_season": "continuous", "annual_global_production_tonnes": "12000", "market_share_top_producer_pct": "58", "supply_chain_length": "1_intermediar…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Trisodium Ethylenediamine Disuccinate.
Regulatory Flags
chelating-agent
biodegradable
edta-alternative
reproductive-effects-high-dose-only
in-vitro-genotoxicity-flag
epa_safer_alternative
Known Synonyms
l-aspartic acid, N,N'-1,2-ethanediylbis-, trisodium salt
UNII-YA22H34H9Q
Natriquest E30
Octaquest E 30
ENVIOMET C 140
EC 416-530-4
Chemical Function
Chelating agent
Regulatory Lists
SCIL (9/2019)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Trisodium Ethylenediamine Disuccinate allowed in the EU?
Trisodium Ethylenediamine Disuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trisodium Ethylenediamine Disuccinate do in cosmetics?
Trisodium Ethylenediamine Disuccinate functions as: Chelating agent; metal ion sequestrant; biodegradable EDTA alternative. It is classified as a cosmetic ingredient in our database. CAS number: 178949-82-1.
Is Trisodium Ethylenediamine Disuccinate used outside cosmetics?
Trisodium Ethylenediamine Disuccinate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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