Is Disodium EDTA safe in cosmetics?
Disodium EDTA has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Disodium EDTA
INCI: DISODIUM EDTA
Disodium EDTA (CAS 139-33-3) is a cosmetic cosmetic ingredient functioning as Chelating agent; metal ion sequestrant; preservative booster. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 139-33-3 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent; metal ion sequestrant; preservative booster
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel concluded safe as used (2002, reaffirmed). GRAS as indirect food additive per 21 CFR 172.120 and 173.315. No pre-market FDA approval required for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium EDTA.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Disodium EDTA.
Regulatory Flags
cir-approved
eu-permitted
penetration-enhancer
not-biodegradable
cosmos-prohibited
eco-concern
hard-water-stable
eu_children_restricted
fda_food_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EDETATE DISODIUM ANHYDROUS
ChEMBL ID
CHEMBL1749
Max Phase
4
Frequently Asked Questions
Is Disodium EDTA allowed in the EU?
Disodium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium EDTA do in cosmetics?
Disodium EDTA functions as: Chelating agent; metal ion sequestrant; preservative booster. It is classified as a cosmetic ingredient in our database. CAS number: 139-33-3.
Is Disodium EDTA used outside cosmetics?
Disodium EDTA also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Disodium EDTA compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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