NOAEL Data REACH Registered Cosmetic Ingredient

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt

Also known as: l-aspartic acid, N,N'-1,2-ethanediylbis-, trisodium salt, UNII-YA22H34H9Q, Natriquest E30, Octaquest E 30, ENVIOMET C 140 (+1 more)

CAS 178949-82-1

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt (CAS 178949-82-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Trisodium Ethylenediamine Disuccinate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt

CAS Number

178949-82-1

DTXSID

DTXSID1051806

Molecular Formula

C10H16N2O8.3Na

InChI Key

QEHXDDFROMGLSP-VDBFCSKJSA-K

Monoisotopic Mass

361.059973

Synonyms

l-aspartic acid, N,N'-1,2-ethanediylbis-, trisodium saltUNII-YA22H34H9QNatriquest E30Octaquest E 30ENVIOMET C 140EC 416-530-4

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

Chelating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
=14.8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
YA22H34H9Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
YA22H34H9Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
YA22H34H9Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
YA22H34H9Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>2700	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
~50	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
~300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~400	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~551	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~8000	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~1250	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	L-Aspartic acid, N,N'-1,2-ethanediylbis-, sodium salt (1:3)	416-530-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for N,N'-Ethylenedi-(L-aspartic acid) trisodium salt?

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt has 15 NOAEL studies in the database. The lowest reported value is 14.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include N,N'-Ethylenedi-(L-aspartic acid) trisodium salt?

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt appears on 1 regulatory/inventory list including SCIL (9/2019). Source: EPA CPDat.

Is N,N'-Ethylenedi-(L-aspartic acid) trisodium salt used in cosmetics?

Yes, N,N'-Ethylenedi-(L-aspartic acid) trisodium salt is also indexed as a cosmetic ingredient under the name Trisodium Ethylenediamine Disuccinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N,N'-Ethylenedi-(L-aspartic acid) trisodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is N,N'-Ethylenedi-(L-aspartic acid) trisodium salt used outside industrial chemicals?

N,N'-Ethylenedi-(L-aspartic acid) trisodium salt also appears in cosmetics databases.