Is TRIETHYLENE GLYCOL DIMETHACRYLATE safe in cosmetics?
TRIETHYLENE GLYCOL DIMETHACRYLATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
TRIETHYLENE GLYCOL DIMETHACRYLATE
Also known as: 2-Propenoic acid, 2-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester, Triethyleneglycol dimethacrylate, 1,2-Bis(2-(methacryloyloxy)ethoxy)ethane, BRN 1797351, EINECS 203-652-6 (+3 more)
TRIETHYLENE GLYCOL DIMETHACRYLATE (CAS 109-16-0) is a cosmetic cosmetic ingredient functioning as Nail Conditioning. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-16-0 →
Auto-generated CPSR Part A draft with source citations
Function
Nail Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate
InChIKey
HWSSEYVMGDIFMH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 24(Suppl 5):53-100, 2005
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for TRIETHYLENE GLYCOL DIMETHACRYLATE across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for TRIETHYLENE GLYCOL DIMETHACRYLATE based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis
Source: IVDK; ESSCA
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1B
Hazard Statements
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "other", "cross_reactivity_group": "acrylate-group", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Methacrylates ... produce slight to moderate skin and eye irritation ... depending upon volatility, these materials also may be sensory irritants. /Methacrylic acid & derivatives/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Chemical reaction regulator
Hardener
Monomers
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for TRIETHYLENE GLYCOL DIMETHACRYLATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
2-Propenoic acid, 2-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
Triethyleneglycol dimethacrylate
1,2-Bis(2-(methacryloyloxy)ethoxy)ethane
BRN 1797351
EINECS 203-652-6
Polyester TGM 3
Triethylene dimethacrylate
UNII-14I47YJ5EY
Chemical Function
Softener and conditioner
Monomers
Adhesion/cohesion promoter
Hardener
Chemical reaction regulator
Regulatory Lists
Europe; Personal care - nails
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187544
Frequently Asked Questions
Is TRIETHYLENE GLYCOL DIMETHACRYLATE allowed in the EU?
TRIETHYLENE GLYCOL DIMETHACRYLATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TRIETHYLENE GLYCOL DIMETHACRYLATE do in cosmetics?
TRIETHYLENE GLYCOL DIMETHACRYLATE functions as: Nail Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 109-16-0.
Is TRIETHYLENE GLYCOL DIMETHACRYLATE used outside cosmetics?
TRIETHYLENE GLYCOL DIMETHACRYLATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check TRIETHYLENE GLYCOL DIMETHACRYLATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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