Is Topiramate safe in cosmetics?
Topiramate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Topiramate
Also known as: 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate, BRN 5988957, RWJ-17021-000, Topiramato, Topiramatum (+11 more)
INCI: TOPIRAMATE
Topiramate (CAS 97240-79-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning (CosIng listing), though primarily known as an. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97240-79-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Topiramate is classified GHS Danger (H351, H360, H371, H372, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning (CosIng listing), though primarily known as an anticonvulsant/pharmaceutical active
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate
InChIKey
KJADKKWYZYXHBB-XBWDGYHZSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-approved drug (Topamax®); cosmetic use would be extremely problematic — any therapeutic claim triggers drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Topiramate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Topiramate.
Regulatory Flags
prop65
Known Synonyms
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
BRN 5988957
RWJ-17021-000
Topiramato
Topiramatum
UNII-0H73WJJ391
Topiragen
Trokendi XR
2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate
McN-4853
RWJ-17021
TPM
Topamax Sprinkle
[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate
tipiramate
tipiramato
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
pharmaceutical
OEHHA Proposition 65 (3/2019)
Canada; pharmaceutical
OEHHA Proposition 65 (1/2023)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TOPIRAMATE
ChEMBL ID
CHEMBL220492
Max Phase
4
Adverse Event Associations
7885
Frequently Asked Questions
Is Topiramate allowed in the EU?
Topiramate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Topiramate do in cosmetics?
Topiramate functions as: Skin conditioning (CosIng listing), though primarily known as an anticonvulsant/pharmaceutical active. It is classified as a cosmetic ingredient in our database. CAS number: 97240-79-4.
Is Topiramate used outside cosmetics?
Topiramate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Topiramate have different safety status in cosmetics vs industrial chemicals?
Topiramate is classified GHS Danger (H351, H360, H371, H372, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Topiramate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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TRACHELOSPERMUM JASMINOIDES EXTRACT
Good
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Skin Conditioning
TRAMETES VERSICOLOR EXTRACT
Good
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Hair Conditioning
TRANS, TRANS-2,4-DECADIENAL
Good
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Perfuming
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