Is Tinosorb S safe in cosmetics?
Tinosorb S has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Tinosorb S
Also known as: Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-, Bis-ethylhexyloxyphenol methoxyphenyl triazine, Bemotrizinol
INCI: TINOSORB S
Tinosorb S (CAS 187393-00-6) is a cosmetic uv filter / sunscreen functioning as UV Filter. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 187393-00-6 →
Auto-generated CPSR Part A draft with source citations
Function
UV Filter
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tinosorb S.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tinosorb S across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LC50 | >649 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LEL | =649 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LEL | ~0.075 mg/cm2-day | Rat | dermal | chronic | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rat | dermal | - | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rat | dermal | - | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rabbit | oral | - | ECHA IUCLID |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: none confirmed in standard assays
LOEC: N/A
EU status: allowed (max 10%)
no significant ER/AR activity
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 10%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 3.0
Korea (Restricted): max 10%
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (6)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| GCC | restricted | 10.0 | Sunscreen products |
| BR | permitted_uv_filter | 10 | Sunscreen products |
| ASEAN | permitted_uv_filter | 10% | - |
Additional Ingredient Properties
4 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,sensitive,combination,normal,acne-prone", "acne_safe": "yes", "source": "Broad spectrum - EU"}
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, broad spectrum", "dry-touch, non-greasy": "protected, minimal-white", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "yes", "light-diffusing": "matte", "1.40": "1.60", "transparent": "opaque", "colorless": "pale-yellow", "excellent": "good", "light": "light", "synthetic": "synthetic"}
skin_suitability
{"oily_skin": "recommended", "dry_skin": "acceptable", "sensitive_skin": "recommended", "combination_skin": "recommended", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "UV-protection", "skin_benefit_secondary": "broad-sp…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Tinosorb S.
Regulatory Flags
eu_cosing_listed
Known Synonyms
Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-
Bis-ethylhexyloxyphenol methoxyphenyl triazine
Bemotrizinol
Chemical Function
UV stabilizer
Softener and conditioner
Regulatory Lists
Europe; Personal care
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BEMOTRIZINOL
ChEMBL ID
CHEMBL2104956
Max Phase
3
Frequently Asked Questions
Is Tinosorb S allowed in the EU?
Tinosorb S EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tinosorb S do in cosmetics?
Tinosorb S functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 187393-00-6.
Is Tinosorb S used outside cosmetics?
Tinosorb S also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tinosorb S compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
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Chemical family
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Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Good
Chemical family
UV filter, sunscreen agent
TIN
Good
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